ATG4B and GABARAPL1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		ATG4B	GABARAPL1
Description		autophagy related 4B cysteine peptidase	GABA type A receptor associated protein like 1
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Cytosol Cytoplasmic Vesicle	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein-phosphatidylethanolamide Deconjugating Activity Scaffold Protein Binding	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Autophagosome Assembly Mitophagy Proteolysis Autophagy Protein Transport Macroautophagy Microautophagy Protein Processing Otolith Mineralization Completed Early In Development Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Aggrephagy Protein Delipidation	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation
Pathways		Macroautophagy	Macroautophagy
Drugs
Diseases
GWAS		Asthma ( 31959851) Body mass index ( 29273807) Carotid intima media thickness ( 30510157) Crohn's disease ( 26192919) Prostate cancer ( 23535732)
Interacting Genes		5 interacting genes: GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B	87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22
Entrez ID		23192	23710
HPRD ID		16499	07601
Ensembl ID		ENSG00000168397	ENSG00000139112
Uniprot IDs		B3KVU2 B7ZA52 Q9Y4P1	Q9H0R8
PDB IDs		2CY7 2D1I 2Z0D 2Z0E 2ZZP 5LXH 5LXI	2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Autophagy Ubiquitin Protein Ligase Binding GABA Receptor Binding Response To Nutrient Levels Organelle Assembly Beta-tubulin Binding Microtubule Binding Cytoplasmic Vesicle Microtubule Protein-containing Complex Organization Cellular Response To Stress Catabolic Process Endomembrane System Cellular Component Assembly Organelle Organization Organelle Membrane Response To Stress Cytoskeleton Axoneme Positive Regulation Of Protein K48-linked Ubiquitination Cellular Response To Oxygen-glucose Deprivation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Response To Iron(II) Ion Ceramide Binding Tat Protein Binding Cytosol Response To Oxygen-glucose Deprivation Glycophagy Autolysosome Golgi Apparatus Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Localization To Endoplasmic Reticulum	Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process
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