PRTFDC1 and HPRT1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, cross-linking study, cross-linking study)
HPRD (two hybrid)

		PRTFDC1	HPRT1
Description		phosphoribosyl transferase domain containing 1	hypoxanthine phosphoribosyltransferase 1
Image
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Metal Ion Binding Guanine Phosphoribosyltransferase Activity
	Biological Process	Purine Ribonucleoside Salvage Guanine Salvage GMP Catabolic Process	T Cell Mediated Cytotoxicity Response To Amphetamine Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Hypoxanthine Salvage AMP Salvage Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Adenine Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization Dopaminergic Neuron Differentiation
Pathways			Purine salvage Defective HPRT1 disrupts guanine and hypoxanthine salvage Azathioprine ADME
Drugs			Mercaptopurine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine 3H-pyrazolo[4,3-d]pyrimidin-7-ol 9-Deazaguanine
Diseases			Lesch-Nyhan syndrome; Hypoxanthine-guanine phosophoribosyltransferase deficiency
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 29617998) Lymphocyte count ( 27863252 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Obesity-related traits ( 23251661) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Post-traumatic stress disorder ( 25456346) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		19 interacting genes: - CNRIP1 DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B LNX1 MCMBP NIF3L1 NTAQ1 SPG21 STAT5A TCL1A TMEM14B VWA5A	11 interacting genes: CEBPA EEF2KMT EFCAB3 FANCA GNMT ISCU NTAQ1 PRTFDC1 SDCBP SPG21 SREK1IP1
Entrez ID		56952	3251
HPRD ID		17917	02388
Ensembl ID		ENSG00000099256	ENSG00000165704
Uniprot IDs		Q9NRG1	A0A140VJL3 P00492
PDB IDs		2JBH	1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA 5W8V 6BNJ 7SAN 8TPY
Enriched GO Terms of Interacting Partners?			Purine Nucleoside Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Negative Regulation Of Iron Ion Import Across Plasma Membrane Iron-sulfur Cluster Chaperone Activity Negative Regulation Of Iron Ion Transmembrane Transport Sarcosine Metabolic Process Nucleoside Metabolic Process Glycine N-methyltransferase Activity S-adenosylhomocysteine Metabolic Process Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage
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