PRTFDC1 and GNPDA1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PRTFDC1	GNPDA1
Description		phosphoribosyl transferase domain containing 1	glucosamine-6-phosphate deaminase 1
Image
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding	Glucosamine-6-phosphate Deaminase Activity Protein Binding Hydrolase Activity Isomerase Activity Identical Protein Binding
	Biological Process	Purine Ribonucleoside Salvage Guanine Salvage GMP Catabolic Process	Carbohydrate Metabolic Process Glucosamine Catabolic Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process Generation Of Precursor Metabolites And Energy Single Fertilization N-acetylneuraminate Catabolic Process
Pathways			Glycolysis
Drugs			Beta-D-Glucose 2-Deoxy-2-Amino Glucitol-6-Phosphate N-acetyl-D-glucosamine-6-phosphate
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 29617998) Lymphocyte count ( 27863252 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Obesity-related traits ( 23251661) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Post-traumatic stress disorder ( 25456346) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	Asthma ( 29273806 31959851) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Mean platelet volume ( 32888494) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		19 interacting genes: - CNRIP1 DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B LNX1 MCMBP NIF3L1 NTAQ1 SPG21 STAT5A TCL1A TMEM14B VWA5A	4 interacting genes: EWSR1 MAGEA11 PRTFDC1 STK11
Entrez ID		56952	10007
HPRD ID		17917	09048
Ensembl ID		ENSG00000099256	ENSG00000113552
Uniprot IDs		Q9NRG1	P46926
PDB IDs		2JBH	1NE7
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway HSP90-CDC37 Chaperone Complex Histone Deacetylase Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Protein-containing Complex ATP-dependent Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Receptor Ligand Inhibitor Activity Aryl Hydrocarbon Receptor Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Telomerase Holoenzyme Complex Assembly LRR Domain Binding Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Magnesium Ion Binding Dendrite Extension Positive Regulation Of Vesicle Transport Along Microtubule Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Purine Ribonucleoside Salvage Guanine Metabolic Process GMP Catabolic Process Purine Nucleobase Biosynthetic Process Adhesion Of Symbiont To Host Cell Virion Attachment To Host Cell Positive Thymic T Cell Selection Anoikis Purine Nucleoside Monophosphate Catabolic Process Nucleoside Salvage Regulation Of Cellular Response To Growth Factor Stimulus Adhesion Of Symbiont To Host Cellular Response To UV-B Golgi Localization Positive T Cell Selection G1 To G0 Transition Protein Kinase Regulator Activity Histone Methyltransferase Binding Chaperone-mediated Protein Complex Assembly Dynein Axonemal Particle Protein Phosphatase Activator Activity Telomere Maintenance Via Telomerase Positive Regulation Of Protein Localization DNA Polymerase Binding Positive Regulation Of Protein Localization To Cell Surface Thymic T Cell Selection
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