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PRTFDC1 and FLAD1
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
HPRD
(two hybrid)
PRTFDC1
FLAD1
Gene Name
phosphoribosyl transferase domain containing 1
flavin adenine dinucleotide synthetase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoplasm
Mitochondrial Matrix
Cytosol
Plasma Membrane
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Hypoxanthine Phosphoribosyltransferase Activity
Protein Homodimerization Activity
FMN Adenylyltransferase Activity
ATP Binding
Biological Process
Purine Ribonucleoside Salvage
Adenine Salvage
Guanine Salvage
GMP Salvage
IMP Salvage
GMP Catabolic Process
Hypoxanthine Metabolic Process
FAD Biosynthetic Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
Riboflavin Metabolic Process
Mo-molybdopterin Cofactor Biosynthetic Process
Small Molecule Metabolic Process
Pathways
Metabolism of vitamins and cofactors
Defective CD320 causes methylmalonic aciduria
Defective GIF causes intrinsic factor deficiency
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective MMAA causes methylmalonic aciduria type cblA
Vitamin B2 (riboflavin) metabolism
Defective CUBN causes hereditary megaloblastic anemia 1
Defective AMN causes hereditary megaloblastic anemia 1
Metabolism of water-soluble vitamins and cofactors
Defective MUT causes methylmalonic aciduria mut type
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Defects in vitamin and cofactor metabolism
Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Prostate cancer (
23535732
)
Protein-Protein Interactions
12 interactors:
DTNB
EEF2KMT
EPM2AIP1
EWSR1
FLAD1
GNPDA1
HPRT1
LGALS9B
MCMBP
NIF3L1
STAT5A
TCL1A
13 interactors:
ANXA7
CDKN1A
GEMIN4
GRB7
NUDT21
PRTFDC1
RCC1
REL
SDCBP
SMN1
TCF4
TK1
TRIM23
Entrez ID
56952
80308
HPRD ID
17917
17887
Ensembl ID
ENSG00000099256
ENSG00000160688
Uniprot IDs
Q9NRG1
Q8NFF5
PDB IDs
2JBH
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Mast Cell Differentiation
GMP Salvage
GMP Catabolic Process
Guanine Salvage
Glucosamine Catabolic Process
FAD Biosynthetic Process
7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process
Regulation Of Mast Cell Differentiation
Adenine Salvage
Dihydrobiopterin Metabolic Process
Hypoxanthine Salvage
Development Of Secondary Male Sexual Characteristics
Positive Regulation Of Dopamine Metabolic Process
Hypoxanthine Metabolic Process
Hypoxanthine Biosynthetic Process
Negative Regulation Of Mast Cell Apoptotic Process
GMP Biosynthetic Process
Positive Regulation Of Glycogen (starch) Synthase Activity
Creatinine Metabolic Process
Regulation Of Mast Cell Apoptotic Process
Purine Nucleoside Monophosphate Catabolic Process
Glucosamine Metabolic Process
Positive Regulation Of Mast Cell Proliferation
Riboflavin Metabolic Process
Isoleucine Metabolic Process
Allantoin Metabolic Process
Purine Ribonucleoside Salvage
Taurine Metabolic Process
Positive Regulation Of Gamma-delta T Cell Differentiation
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Response To Organonitrogen Compound
Heterocycle Metabolic Process
Negative Regulation Of Erythrocyte Differentiation
Prolactin Signaling Pathway
GMP Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Positive Regulation Of Gamma-delta T Cell Activation
Development Of Secondary Female Sexual Characteristics
Valine Metabolic Process
Creatine Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Natural Killer Cell Differentiation
Succinate Metabolic Process
Regulation Of Glycogen (starch) Synthase Activity
Regulation Of Gamma-delta T Cell Differentiation
Development Of Secondary Sexual Characteristics
Purine Ribonucleoside Catabolic Process
Luteinization
Positive Regulation Of Glycogen Biosynthetic Process
Cellular Component Assembly
Digestive Tract Development
Digestive System Development
Ribonucleoprotein Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Cellular Macromolecular Complex Assembly
Spliceosomal SnRNP Assembly
Negative Regulation Of Gene Expression
Ribonucleoprotein Complex Biogenesis
Fetal Process Involved In Parturition
RNA Splicing
Skeletal Muscle Cell Proliferation
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
MRNA Processing
Protein Tetramerization
Response To Extracellular Stimulus
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Regulation Of Cellular Component Organization
Positive Regulation Of Extracellular Vesicular Exosome Assembly
Maintenance Of DNA Repeat Elements
MRNA Metabolic Process
Cell Cycle Arrest
Intestinal Epithelial Cell Maturation
RNA Processing
Positive Regulation Of Signal Transduction
Response To Glucocorticoid
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Extracellular Vesicular Exosome Assembly
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Response To Cortisol
Thymidine Metabolic Process
Embryonic Hindgut Morphogenesis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Corticosteroid
Small GTPase Mediated Signal Transduction
Embryonic Genitalia Morphogenesis
Response To Toxic Substance
Positive Regulation Of Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Cellular Response To UV-B
Myoblast Fate Commitment
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Ran GTPase Activity
Tube Development
Secretory Granule Localization
Pyrimidine Nucleoside Salvage
Pyrimidine-containing Compound Salvage
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Tagcloud (Intersection)
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