PRTFDC1 and VWA5A

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PRTFDC1	VWA5A
Name		phosphoribosyl transferase domain containing 1	von Willebrand factor A domain containing 5A
Structure			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding
	Biological Process	Purine Ribonucleoside Salvage Guanine Salvage GMP Catabolic Process	None
GWAS		A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Diisocyanate-induced asthma ( 25918132 ) Eosinophil count ( 32888494 ) Granulocyte count ( 27863252 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Intraocular pressure ( 29617998 ) Lymphocyte count ( 27863252 32888494 ) Metabolite levels (Pyroglutamine) ( 23934736 ) Monocyte count ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Obesity-related traits ( 23251661 ) Perceived intensity of neohesperidin dihydrochalcone ( 31005972 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Post-traumatic stress disorder ( 25456346 ) Red cell distribution width ( 27863252 32888494 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 32888494 )	Aging (time to death) ( 21782286 )
Novel Interactors		2 novel interactors: GPR158 RAB18	3 novel interactors: DRD2 KMT2A RDX
Interacting Genes		19 interacting genes: - CNRIP1 DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B LNX1 MCMBP NIF3L1 NTAQ1 SPG21 STAT5A TCL1A TMEM14B VWA5A	6 interacting genes: APP MEOX2 PPARA PRTFDC1 RHOU SPSB1
Entrez ID		56952	4013
HPRD ID		17917	04238
Ensembl ID		ENSG00000099256	ENSG00000110002
Uniprot IDs		Q9NRG1	O00534
PDB IDs		2JBH	Not available
GO Terms Enriched among Interactors		None	Regulation Of Neuronal Synaptic Plasticity Visual Behavior Visual Learning Circadian Regulation Of Gene Expression Associative Learning Circadian Rhythm Adult Behavior Positive Regulation Of Long-term Synaptic Potentiation Learning Regulation Of Neurotransmitter Uptake Negative Regulation Of MiRNA Transcription Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Receptor Internalization Lipoprotein Metabolic Process Regulation Of Synaptic Plasticity Positive Regulation Of ATP Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Long-term Synaptic Potentiation Rhythmic Process Negative Regulation Of Blood Pressure Positive Regulation Of Gene Expression, Epigenetic Learning Or Memory Regulation Of Glycolytic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Receptor-mediated Endocytosis Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Cognition Response To Metal Ion Response To Light Stimulus Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of Carbohydrate Catabolic Process Regulation Of Multicellular Organism Growth Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Biological Quality Regulation Of Receptor Internalization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Adult Locomotory Behavior