PRTFDC1 and NIF3L1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PRTFDC1	NIF3L1
Gene Name		phosphoribosyl transferase domain containing 1	NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Mitochondrion
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Homodimerization Activity	GTP Cyclohydrolase I Activity Protein Binding GTP Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage GMP Salvage IMP Salvage GMP Catabolic Process Hypoxanthine Metabolic Process	7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		12 interactors: DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B MCMBP NIF3L1 STAT5A TCL1A	64 interactors: AP5B1 APIP ARPIN BEND7 CCDC102B CCDC85B CDKN2B CDKN2C COIL COPS2 CUTC DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DUSP23 DYNLT3 EIF5A2 ENOX1 EPHB6 FAM49B FXR2 GNMT GRB2 KCTD17 KRT15 KXD1 LAMTOR3 LMO2 MAGEA11 MAPRE2 MLXIPL NATD1 NME1 NOL3 NUDT14 NUDT21 ORC5 PAICS PCBD1 PRTFDC1 RABAC1 RAD54B RPIA S100A1 SAT1 SNF8 STAT3 STK16 SULT1A2 SULT1A3 SYT17 THOC7 TIFA TRAF2 TRIM21 TRIP13 TSC22D4 VIM YES1 YWHAQ ZBED1
Entrez ID		56952	60491
HPRD ID		17917	10424
Ensembl ID		ENSG00000099256	ENSG00000196290
Uniprot IDs		Q9NRG1	Q9GZT8
PDB IDs		2JBH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mast Cell Differentiation GMP Salvage GMP Catabolic Process Guanine Salvage Glucosamine Catabolic Process FAD Biosynthetic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Mast Cell Differentiation Adenine Salvage Dihydrobiopterin Metabolic Process Hypoxanthine Salvage Development Of Secondary Male Sexual Characteristics Positive Regulation Of Dopamine Metabolic Process Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mast Cell Apoptotic Process GMP Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Creatinine Metabolic Process Regulation Of Mast Cell Apoptotic Process Purine Nucleoside Monophosphate Catabolic Process Glucosamine Metabolic Process Positive Regulation Of Mast Cell Proliferation Riboflavin Metabolic Process Isoleucine Metabolic Process Allantoin Metabolic Process Purine Ribonucleoside Salvage Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Response To Organonitrogen Compound Heterocycle Metabolic Process Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway GMP Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Succinate Metabolic Process Regulation Of Glycogen (starch) Synthase Activity Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Purine Ribonucleoside Catabolic Process Luteinization Positive Regulation Of Glycogen Biosynthetic Process	Protein Oligomerization Nucleobase-containing Compound Metabolic Process Protein Tetramerization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nitrogen Compound Metabolic Process Nucleoside Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Protein Complex Assembly Protein Homotetramerization Purine Nucleoside Metabolic Process Protein Homooligomerization Peptidyl-lysine Modification To Peptidyl-hypusine Polyamine Metabolic Process Polyamine Catabolic Process Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination Nucleotide Metabolic Process Amine Metabolic Process Ribonucleotide Metabolic Process Biosynthetic Process Cellular Metabolic Process Purine Nucleotide Metabolic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process Regulation Of Protein Homodimerization Activity Cellular Component Assembly Sulfation Sulfur Compound Metabolic Process Positive Regulation Of T Cell Activation Gene Expression Amine Biosynthetic Process Oocyte Maturation Positive Regulation Of Homotypic Cell-cell Adhesion Transcription, DNA-templated Regulation Of Glycolytic Process Meiosis I Organophosphate Metabolic Process Male Meiosis I Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell-cell Adhesion RNA Biosynthetic Process Response To Injury Involved In Regulation Of Muscle Adaptation Deoxyhypusine Biosynthetic Process From Spermidine Glucose Mediated Signaling Pathway Polyamine Homeostasis Response To Brefeldin A
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