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PRTFDC1 and STAT5A
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PRTFDC1
STAT5A
Description
phosphoribosyl transferase domain containing 1
signal transducer and activator of transcription 5A
Image
GO Annotations
Cellular Component
Cytosol
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Hypoxanthine Phosphoribosyltransferase Activity
Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Phosphate Ion Binding
Sequence-specific DNA Binding
DNA-binding Transcription Factor Binding
Biological Process
Purine Ribonucleoside Salvage
Guanine Salvage
GMP Catabolic Process
Mitotic Cell Cycle
Luteinization
Natural Killer Cell Differentiation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Lymphocyte Differentiation
Regulation Of Cell Adhesion
B Cell Differentiation
Erythrocyte Differentiation
Eosinophil Differentiation
Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Differentiation
Mast Cell Apoptotic Process
Negative Regulation Of Mast Cell Apoptotic Process
Myeloid Cell Apoptotic Process
Negative Regulation Of Myeloid Cell Apoptotic Process
T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Reelin-mediated Signaling Pathway
Interleukin-5-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Thrombopoietin-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Natural Killer Cell Mediated Cytotoxicity
Gamma-delta T Cell Differentiation
T Cell Homeostasis
Response To Peptide Hormone
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Activated T Cell Proliferation
Mast Cell Differentiation
Positive Regulation Of Mast Cell Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Prostate Gland Epithelium Morphogenesis
Epithelial Cell Differentiation Involved In Prostate Gland Development
Mammary Gland Epithelium Development
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Regulation Of Hemopoiesis
Negative Regulation Of T-helper 17 Cell Lineage Commitment
Pathways
Prolactin receptor signaling
Nuclear signaling by ERBB4
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Inactivation of CSF3 (G-CSF) signaling
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Appendicular lean mass (
33097823
)
Diisocyanate-induced asthma (
25918132
)
Eosinophil count (
32888494
)
Granulocyte count (
27863252
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
27863252
32888494
)
Intraocular pressure (
29617998
)
Lymphocyte count (
27863252
32888494
)
Metabolite levels (Pyroglutamine) (
23934736
)
Monocyte count (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Obesity-related traits (
23251661
)
Perceived intensity of neohesperidin dihydrochalcone (
31005972
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Post-traumatic stress disorder (
25456346
)
Red cell distribution width (
27863252
32888494
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
27863252
32888494
)
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
23128233
27569725
28067908
)
Low density lipoprotein cholesterol levels (
32154731
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
19 interacting genes:
-
CNRIP1
DTNB
EEF2KMT
EPM2AIP1
EWSR1
FLAD1
GNPDA1
HPRT1
LGALS9B
LNX1
MCMBP
NIF3L1
NTAQ1
SPG21
STAT5A
TCL1A
TMEM14B
VWA5A
72 interacting genes:
AQP11
BMX
BRCA1
BRCA2
BTK
CBL
CCR5
CD247
CEBPB
CPAP
CRK
CRKL
CSNK2B
CTLA4
CYP2C9
EGFR
EP300
EPAS1
EPOR
ERBB4
ESR1
ESR2
FBXW7
FN1
GHR
GLUD1
GNB2
HELZ
IL2RB
IL2RG
IL7R
INSR
JAK1
JAK2
JAK3
KIT
LCK
MAGEA12
MAPK1
MAPK3
MRPS6
NCOR2
NMI
NR3C1
OLIG1
PDGFRA
PDGFRB
POM121C
POU2F1
PPIB
PPP2CA
PRMT1
PRTFDC1
PTPN1
PTPN11
PTPN2
RBMX
SHC1
SRC
STAP2
STAT1
STAT3
STAT5B
SYK
TCF12
TEK
TET2
TSLP
TXNDC11
UGT2B4
WASH2P
ZNF596
Entrez ID
56952
6776
HPRD ID
17917
03301
Ensembl ID
ENSG00000099256
ENSG00000126561
Uniprot IDs
Q9NRG1
A0A384N5W4
A0A7I2YQF1
A8K6I5
K7EK35
P42229
Q59GY7
PDB IDs
2JBH
7TVA
7TVB
7UBT
7UC6
7UC7
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cytokine-mediated Signaling Pathway
Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Cell Surface Receptor Signaling Pathway Via STAT
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-7-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune System Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Phosphorylation
Phosphotyrosine Residue Binding
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Developmental Process
Animal Organ Development
Regulation Of ERK1 And ERK2 Cascade
Protein Phosphorylation
Regulation Of Multicellular Organismal Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Developmental Process
Response To Growth Factor
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Activity
Regulation Of Gene Expression
Regulation Of Immune Response
Identical Protein Binding
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Tagcloud
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Tagcloud (Intersection)
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