PRTFDC1 and -

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRTFDC1	-
Description		phosphoribosyl transferase domain containing 1	salt inducible kinase 1B (putative)
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Purine Ribonucleoside Salvage Guanine Salvage GMP Catabolic Process
Pathways			Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs			Dabrafenib Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 29617998) Lymphocyte count ( 27863252 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Obesity-related traits ( 23251661) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Post-traumatic stress disorder ( 25456346) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		19 interacting genes: - CNRIP1 DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B LNX1 MCMBP NIF3L1 NTAQ1 SPG21 STAT5A TCL1A TMEM14B VWA5A	6 interacting genes: GINS4 LHX8 MESD PITX1 PRTFDC1 TIMM10
Entrez ID		56952	102724428
HPRD ID		17917
Ensembl ID		ENSG00000099256	ENSG00000275993
Uniprot IDs		Q9NRG1	P57059
PDB IDs		2JBH
Enriched GO Terms of Interacting Partners?			Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering TIM22 Mitochondrial Import Inner Membrane Insertion Complex Mitochondrial Intermembrane Space Chaperone Complex Purine Nucleoside Monophosphate Catabolic Process Purine Ribonucleoside Salvage Hypoxanthine Phosphoribosyltransferase Activity Nucleoside Salvage Guanine Salvage Guanine Metabolic Process GMP Catabolic Process Purine Nucleobase Biosynthetic Process CMG Complex Double-strand Break Repair Via Break-induced Replication GINS Complex
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