MLLT10 and NDEL1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		MLLT10	NDEL1
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	nudE neurodevelopment protein 1-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nucleolus Cytoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding	Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding Oligopeptidase Activity
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axon Cargo Transport Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Activation Of Cdc42 GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Neuron Projection Extension
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Meningioma ( 21804547) Ovarian cancer ( 23535730)
Protein-Protein Interactions		7 interactors: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4	58 interactors: AIMP2 ANK2 APP BMI1 CCDC88A CCHCR1 CCSER1 CCSER2 CDK5 CENPF CEP170 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 GOLGA2 IMMT KALRN KIFC3 KRT40 LUC7L2 MAGEA11 MBIP MIS18A MLLT10 MRC2 MTUS2 NDC80 NDE1 PAFAH1B1 PKP2 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TRIM27 USP2 XPA YWHAE YWHAG ZNF10 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF260 ZNF264 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF844 ZNF91
Entrez ID		8028	81565
HPRD ID		03874	06340
Ensembl ID		ENSG00000078403	ENSG00000166579
Uniprot IDs		P55197 Q59EQ6 Q6N002	Q9GZM8
PDB IDs			2V66
Enriched GO Terms of Interacting Partners?		Cerebral Cortex Radially Oriented Cell Migration Microtubule Cytoskeleton Organization Cerebral Cortex Cell Migration Histone H3-K79 Methylation Telencephalon Cell Migration Forebrain Cell Migration Organelle Organization Cerebral Cortex Development Neuron Migration Microtubule-based Process Pallium Development Positive Regulation Of Axon Regeneration Retrograde Axon Cargo Transport Peptidyl-lysine Modification Positive Regulation Of Neuron Projection Regeneration Activation Of Cdc42 GTPase Activity Mitotic Centrosome Separation Telencephalon Development Neurofilament Cytoskeleton Organization Cytoskeleton Organization Centrosome Separation Mitotic Nuclear Division Regulation Of Axon Regeneration Histone H2A Acetylation Positive Regulation Of Cdc42 GTPase Activity Regulation Of Metabolic Process Regulation Of Neuron Projection Development Mitochondrial Calcium Ion Homeostasis Histone Modification Inner Cell Mass Cell Proliferation Positive Regulation Of Neurogenesis Regulation Of Synapse Maturation Neuronal Stem Cell Maintenance Microtubule Nucleation TOR Signaling Forebrain Development Protein Targeting To Golgi Regulation Of Cdc42 GTPase Activity Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription Regulatory Region DNA Binding Blastocyst Growth Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Centrosome Localization	G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Cerebral Cortex Development Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Cell Division Pallium Development Cell Cycle Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Telencephalon Development Organelle Organization Cytoskeleton Organization Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Neural Precursor Cell Proliferation Microtubule-based Process Microtubule Cytoskeleton Organization Forebrain Development Regulation Of Gene Expression Cellular Process Cerebral Cortex Radially Oriented Cell Migration Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Regulation Of Heart Rate By Cardiac Conduction Organelle Localization Brain Development Neuron Migration Head Development Cerebral Cortex Cell Migration Movement Of Cell Or Subcellular Component Cell Cycle Process Mitotic Nuclear Division Establishment Of Organelle Localization Telencephalon Cell Migration Cardiac Muscle Cell Action Potential Forebrain Cell Migration Cellular Localization
Tagcloud ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 nkx2 normalization normalizations obtaining perturbations pipelines plag1 ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels
Tagcloud (Difference) ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 nkx2 normalization normalizations obtaining perturbations pipelines plag1 ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels
Tagcloud (Intersection) ?