MLLT10 and DISC1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		MLLT10	DISC1
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	disrupted in schizophrenia 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Meningioma ( 21804547) Ovarian cancer ( 23535730)	Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		7 interactors: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4	113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		8028	27185
HPRD ID		03874	05553
Ensembl ID		ENSG00000078403	ENSG00000162946
Uniprot IDs		P55197 Q59EQ6 Q6N002	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebral Cortex Radially Oriented Cell Migration Microtubule Cytoskeleton Organization Cerebral Cortex Cell Migration Histone H3-K79 Methylation Telencephalon Cell Migration Forebrain Cell Migration Organelle Organization Cerebral Cortex Development Neuron Migration Microtubule-based Process Pallium Development Positive Regulation Of Axon Regeneration Retrograde Axon Cargo Transport Peptidyl-lysine Modification Positive Regulation Of Neuron Projection Regeneration Activation Of Cdc42 GTPase Activity Mitotic Centrosome Separation Telencephalon Development Neurofilament Cytoskeleton Organization Cytoskeleton Organization Centrosome Separation Mitotic Nuclear Division Regulation Of Axon Regeneration Histone H2A Acetylation Positive Regulation Of Cdc42 GTPase Activity Regulation Of Metabolic Process Regulation Of Neuron Projection Development Mitochondrial Calcium Ion Homeostasis Histone Modification Inner Cell Mass Cell Proliferation Positive Regulation Of Neurogenesis Regulation Of Synapse Maturation Neuronal Stem Cell Maintenance Microtubule Nucleation TOR Signaling Forebrain Development Protein Targeting To Golgi Regulation Of Cdc42 GTPase Activity Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription Regulatory Region DNA Binding Blastocyst Growth Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Centrosome Localization	Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization
Tagcloud ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 nkx2 normalization normalizations obtaining perturbations pipelines plag1 ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Difference) ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 nkx2 normalization normalizations obtaining perturbations pipelines plag1 ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Intersection) ?