NDEL1 and CENPF

Number of citations of the paper that reports this interaction (PMID 17600710)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NDEL1	CENPF
Gene Name		nudE neurodevelopment protein 1-like 1	centromere protein F, 350/400kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nucleolus Cytoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Spindle Cytosol Nuclear Matrix Midbody Pronucleus Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding Oligopeptidase Activity	Chromatin Binding Protein Binding Protein C-terminus Binding Transcription Factor Binding Protein Homodimerization Activity Dynein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axon Cargo Transport Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Activation Of Cdc42 GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Neuron Projection Extension	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Muscle Organ Development Cell Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Cell Differentiation Response To Drug Negative Regulation Of Transcription, DNA-templated Cell Division Metaphase Plate Congression Kinetochore Assembly Regulation Of Cell Cycle DNA Biosynthetic Process
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion G2/M Transition Mitotic Anaphase Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Polo-like kinase mediated events Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Response to antineoplastic agents ( 21659360)
Protein-Protein Interactions		58 interactors: AIMP2 ANK2 APP BMI1 CCDC88A CCHCR1 CCSER1 CCSER2 CDK5 CENPF CEP170 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 GOLGA2 IMMT KALRN KIFC3 KRT40 LUC7L2 MAGEA11 MBIP MIS18A MLLT10 MRC2 MTUS2 NDC80 NDE1 PAFAH1B1 PKP2 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TRIM27 USP2 XPA YWHAE YWHAG ZNF10 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF260 ZNF264 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF844 ZNF91	10 interactors: BRAP CENPE CHMP2B FNTA FNTB NDEL1 NUP133 SNAP25 SVIL TOP3B
Entrez ID		81565	1063
HPRD ID		06340	02582
Ensembl ID		ENSG00000166579	ENSG00000117724
Uniprot IDs		Q9GZM8	P49454
PDB IDs		2V66
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Cerebral Cortex Development Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Cell Division Pallium Development Cell Cycle Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Telencephalon Development Organelle Organization Cytoskeleton Organization Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Neural Precursor Cell Proliferation Microtubule-based Process Microtubule Cytoskeleton Organization Forebrain Development Regulation Of Gene Expression Cellular Process Cerebral Cortex Radially Oriented Cell Migration Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Regulation Of Heart Rate By Cardiac Conduction Organelle Localization Brain Development Neuron Migration Head Development Cerebral Cortex Cell Migration Movement Of Cell Or Subcellular Component Cell Cycle Process Mitotic Nuclear Division Establishment Of Organelle Localization Telencephalon Cell Migration Cardiac Muscle Cell Action Potential Forebrain Cell Migration Cellular Localization	Establishment Of Chromosome Localization Protein Farnesylation Chromosome Segregation Establishment Of Organelle Localization Nucleus Organization Protein Prenylation Organelle Localization Regulation Of Cell Cycle Regulation Of Rhodopsin Mediated Signaling Pathway Mitotic Metaphase Plate Congression Organelle Organization Rhodopsin Mediated Signaling Pathway Metaphase Plate Congression Nuclear Envelope Disassembly Mitotic Cell Cycle Process Regulation Of Cell Division Mitotic Cell Cycle Positive Regulation Of Cell Cycle Mitotic Nuclear Division Membrane Organization Nuclear Envelope Organization Cellular Protein Complex Assembly Positive Regulation Of Tubulin Deacetylation Phototransduction, Visible Light Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Establishment Of Localization In Cell Detection Of Light Stimulus Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Mitotic Chromosome Movement Towards Spindle Pole Cellular Response To Radiation Cell Cycle Wound Healing Cellular Localization Cellular Macromolecular Complex Assembly Regulation Of Tubulin Deacetylation Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Positive Regulation Of Axon Regeneration Positive Regulation Of Deacetylase Activity Response To Wounding Retrograde Axon Cargo Transport Viral Budding Via Host ESCRT Complex Viral Life Cycle
Tagcloud ?		ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels	assembled causal computational coordinated cross drivers engineered foxm1 genetically genome indicator interactomes interrogation malignancy master networks profiles promote prostate regulators regulatory represents robust shows synergistic synergistically validation valuable wide
Tagcloud (Difference) ?		ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels	assembled causal computational coordinated cross drivers engineered foxm1 genetically genome indicator interactomes interrogation malignancy master networks profiles promote prostate regulators regulatory represents robust shows synergistic synergistically validation valuable wide
Tagcloud (Intersection) ?