NDEL1 and CEP170

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		NDEL1	CEP170
Description		nudE neurodevelopment protein 1 like 1	centrosomal protein 170
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Synaptic Vesicle Axon Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Axon Cytoplasm	Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Ciliary Basal Body Centriolar Subdistal Appendage
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Beta-tubulin Binding	Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Neuron Migration Inner Cell Mass Cell Proliferation Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Cell Differentiation Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Vesicle Transport Along Microtubule Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Ruffle Assembly Neuron Projection Extension
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Bronchopulmonary dysplasia ( 23897914) Chromium levels ( 26025379) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31015462) Lung cancer in ever smokers ( 28604730) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 23823483) Red cell distribution width ( 28957414 32888494) Schizophrenia ( 23974872) Smoking behaviour (cigarettes smoked per day) ( 31217584) Systemising ( 31508503)
Interacting Genes		85 interacting genes: ABI3 ACTB AIMP2 AKAP9 ANK2 APP BMI1 BORCS6 BRK1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 LUC7L2 MAGEA11 MBIP MED11 MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PARVG PICK1 PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TUBB USP2 XPA YWHAE YWHAG ZC2HC1C ZNF10 ZNF12 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF250 ZNF260 ZNF264 ZNF3 ZNF35 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF662 ZNF707 ZNF844 ZNF91	8 interacting genes: CEBPA NDEL1 PPP1CA PTEN SNAPIN SRPK2 VAV2 YWHAG
Entrez ID		81565	9859
HPRD ID		06340	17172
Ensembl ID		ENSG00000166579	ENSG00000143702
Uniprot IDs		A6NIZ0 Q9GZM8	Q5SW79
PDB IDs		2V66	4JON
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Cytoskeleton Microtubule Cell Division Kinesin Complex Microtubule Binding Microtubule Cytoskeleton Organization Cytoskeleton Organization Centrosome Nucleus Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of RNA Biosynthetic Process DNA Binding Cytoskeleton-dependent Intracellular Transport Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Maintenance Of Location In Cell Organelle Organization Kinesin Binding Maintenance Of Location Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasmic Microtubule Organization Organelle Localization Acetylcholine Receptor Activator Activity Microtubule-based Movement Regulation Of Heart Rate By Cardiac Conduction Metal Ion Binding Establishment Of Organelle Localization Regulation Of Cell Cycle Microtubule Organizing Center Organization Central Region Of Growth Cone Protein Binding Cardiac Conduction Protein Kinase C Binding Retrograde Axonal Transport Presynapse Kinetochore Supramolecular Fiber Organization Maintenance Of Protein Location In Cell Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Motor Activity	Organelle Organization Developmental Maturation Intracellular Signaling Cassette Cellular Response To Xenobiotic Stimulus RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Developmental Process Presynapse Protein Stabilization Protein Dephosphorylation Phosphatase Activity Regulation Of Protein Stability RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Protein Serine/threonine Phosphatase Activity Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Cell Projection Organization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Neuron Axonogenesis Cell Migration Cell Projection Organization Microtubule-based Process Regulation Of Cellular Component Size Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Size Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Vesicle Cytoskeletal Trafficking Retrograde Axonal Transport Positive Regulation Of Late Endosome To Lysosome Transport Vesicle Transport Along Microtubule Lysosome Localization Axon Cytoplasm Axonal Transport Axo-dendritic Transport Organelle Transport Along Microtubule Neurofilament Cytoskeleton Intracellular Signal Transduction Regulation Of Neuron Projection Development Lung Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Translational Initiation Negative Regulation Of Protein Phosphorylation Cell Motility Establishment Of Vesicle Localization CHOP-C/EBP Complex Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
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