MLLT10 and SS18

Number of citations of the paper that reports this interaction (PubMedID 11423977)
0

Data Source:
HPRD (in vivo, two hybrid)

		MLLT10	SS18
Description		MLLT10 histone lysine methyltransferase DOT1L cofactor	SS18 subunit of BAF chromatin remodeling complex
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton SWI/SNF Complex NpBAF Complex GBAF Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Histone Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Microtubule Cytoskeleton Organization Cell Morphogenesis Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Intracellular Signal Transduction Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Neuronal Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance
Pathways			Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases			Synovial sarcoma
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737 33830993) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Smoking initiation ( 33082346) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800) Walking pace ( 33128006)	Autoimmune thyroid disease ( 32581359) Daytime nap ( 33568662) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Mean corpuscular hemoglobin ( 32888494) Nickel levels ( 26025379) Obesity-related traits ( 23251661) Periodontitis (Mean PAL) ( 24024966) QT interval (sulfonylurea treatment interaction) ( 27958378) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Toenail selenium levels ( 25343990)
Interacting Genes		16 interacting genes: DISC1 DOT1L EPS15 FOXI1 HNF1B HPCA MLLT1 NCALD NDEL1 POU2F1 POU6F2 RBPMS RGPD5 SS18 VEZF1 YEATS4	9 interacting genes: EP300 FUS GRB2 H3-3A MLLT10 NFKBID RBM14 SMARCA2 SMARCA4
Entrez ID		8028	6760
HPRD ID		03874	02559
Ensembl ID		ENSG00000078403	ENSG00000141380
Uniprot IDs		P55197 Q59EQ6	B4DLD3 B4DR34 Q15532 Q4VAX0
PDB IDs		5DAG 5DAH 6CKN 6CKO 6JN2 7MJU	7VRB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cerebral Cortex Radially Oriented Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Cerebral Cortex Cell Migration Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Electrical Stimulus Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Telencephalon Cell Migration Forebrain Cell Migration Kinesin Complex Alpha-tubulin Binding Histone H3K79 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Response To Ketamine Hepatoblast Differentiation Regulation Of Pronephros Size Histone H3K18ac Reader Activity Neurofilament Cytoskeleton Regulation Of Stem Cell Population Maintenance Transcription Coactivator Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Histone H3K27ac Reader Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of Gene Expression	Epigenetic Regulation Of Gene Expression Transcription Coactivator Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Cell Adhesion Transcription Initiation-coupled Chromatin Remodeling Regulation Of T Cell Differentiation Chromatin Binding Regulation Of Cell-cell Adhesion Nucleosome Array Spacer Activity Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of Lymphocyte Differentiation Regulation Of Organelle Organization Regulation Of Cell Activation Chromatin Remodeling BBAF Complex Positive Regulation Of Double-strand Break Repair Positive Regulation Of T-helper 17 Cell Differentiation NpBAF Complex GBAF Complex Regulation Of Cell Adhesion Chromatin Organization NBAF Complex Host-mediated Activation Of Viral Transcription Regulation Of Immune System Process Activation Of Immune Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Hemopoiesis Positive Regulation Of DNA Repair Heterochromatin Formation Positive Regulation Of Cell Development Regulation Of Double-strand Break Repair Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Histone Binding Nuclear Androgen Receptor Binding Positive Regulation Of T-helper Cell Differentiation
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