MLLT10 and DOT1L

Number of citations of the paper that reports this interaction (PMID 15851025)
151

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		MLLT10	DOT1L
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	DOT1-like histone H3K79 methyltransferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding	DNA Binding Protein Binding Transcription Factor Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K79 Specific)
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Chromatin Silencing Histone H3-K79 Methylation Regulation Of JAK-STAT Cascade Regulation Of Cell Cycle Regulation Of Transcription Regulatory Region DNA Binding
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Meningioma ( 21804547) Ovarian cancer ( 23535730)	Height ( 20881960 23563607 18391950) Osteoarthritis ( 22566624)
Protein-Protein Interactions		7 interactors: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4	4 interactors: HIST3H3 MLLT10 MLLT6 STAT1
Entrez ID		8028	84444
HPRD ID		03874	10455
Ensembl ID		ENSG00000078403	ENSG00000104885
Uniprot IDs		P55197 Q59EQ6 Q6N002	Q8TEK3
PDB IDs			1NW3 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA
Enriched GO Terms of Interacting Partners?		Cerebral Cortex Radially Oriented Cell Migration Microtubule Cytoskeleton Organization Cerebral Cortex Cell Migration Histone H3-K79 Methylation Telencephalon Cell Migration Forebrain Cell Migration Organelle Organization Cerebral Cortex Development Neuron Migration Microtubule-based Process Pallium Development Positive Regulation Of Axon Regeneration Retrograde Axon Cargo Transport Peptidyl-lysine Modification Positive Regulation Of Neuron Projection Regeneration Activation Of Cdc42 GTPase Activity Mitotic Centrosome Separation Telencephalon Development Neurofilament Cytoskeleton Organization Cytoskeleton Organization Centrosome Separation Mitotic Nuclear Division Regulation Of Axon Regeneration Histone H2A Acetylation Positive Regulation Of Cdc42 GTPase Activity Regulation Of Metabolic Process Regulation Of Neuron Projection Development Mitochondrial Calcium Ion Homeostasis Histone Modification Inner Cell Mass Cell Proliferation Positive Regulation Of Neurogenesis Regulation Of Synapse Maturation Neuronal Stem Cell Maintenance Microtubule Nucleation TOR Signaling Forebrain Development Protein Targeting To Golgi Regulation Of Cdc42 GTPase Activity Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription Regulatory Region DNA Binding Blastocyst Growth Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Centrosome Localization See more	Negative Regulation Of Macrophage Fusion Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesenchymal Cell Differentiation Involved In Kidney Development Cell Proliferation Involved In Metanephros Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Differentiation Involved In Metanephros Development Cellular Response To Interferon-beta Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Metanephric Mesenchyme Development Response To Interferon-beta Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Growth Hormone Cell Differentiation Involved In Kidney Development Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mesenchymal Cell Proliferation Response To Exogenous DsRNA Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling JAK-STAT Cascade Positive Regulation Of Smooth Muscle Cell Proliferation See more
Tagcloud ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 nkx2 normalization normalizations obtaining perturbations pipelines plag1 ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	aberrant balanced blasts catalyze considerable depending deregulated disturbed drivers histones indirectly leukemia leukemic lysine marks methylated methyltransferases mll1 oncogenic originating progenitor recurrently repressing residue setd2 tightly transformed translocations writers
Tagcloud (Difference) ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 nkx2 normalization normalizations obtaining perturbations pipelines plag1 ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	aberrant balanced blasts catalyze considerable depending deregulated disturbed drivers histones indirectly leukemia leukemic lysine marks methylated methyltransferases mll1 oncogenic originating progenitor recurrently repressing residue setd2 tightly transformed translocations writers
Tagcloud (Intersection) ?