MLLT10 and DOT1L

Number of citations of the paper that reports this interaction (PubMedID 31527241)
27

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vivo, two hybrid)

		MLLT10	DOT1L
Description		MLLT10 histone lysine methyltransferase DOT1L cofactor	DOT1 like histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Histone Binding Metal Ion Binding	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Protein Binding Methyltransferase Activity Transferase Activity Histone H3K79 Methyltransferase Activity Histone Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization Gene Expression Heterochromatin Formation Subtelomeric Heterochromatin Formation Telomere Organization Methylation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Cycle Regulation Of Transcription Regulatory Region DNA Binding
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737 33830993) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Smoking initiation ( 33082346) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800) Walking pace ( 33128006)	Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 23563607 25282103 18391950 28552196) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878 30578418 30487518 29403010 26390057 27618448) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33493351) Systolic blood pressure ( 30487518 27618448) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: DISC1 DOT1L EPS15 FOXI1 HNF1B HPCA MLLT1 NCALD NDEL1 POU2F1 POU6F2 RBPMS RGPD5 SS18 VEZF1 YEATS4	6 interacting genes: H3-4 MAPK11 MLLT10 MYCN STAT1 UBE3C
Entrez ID		8028	84444
HPRD ID		03874	10455
Ensembl ID		ENSG00000078403	ENSG00000104885
Uniprot IDs		P55197 Q59EQ6	A0A8I5QL06 Q8TEK3
PDB IDs		5DAG 5DAH 6CKN 6CKO 6JN2 7MJU	1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96 6TE6 6TEL 6TEN 7BWD 7EDP 7S7E 7S7F 7XCR 7XCT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cerebral Cortex Radially Oriented Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Cerebral Cortex Cell Migration Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Electrical Stimulus Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Telencephalon Cell Migration Forebrain Cell Migration Kinesin Complex Alpha-tubulin Binding Histone H3K79 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Response To Ketamine Hepatoblast Differentiation Regulation Of Pronephros Size Histone H3K18ac Reader Activity Neurofilament Cytoskeleton Regulation Of Stem Cell Population Maintenance Transcription Coactivator Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Histone H3K27ac Reader Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of Gene Expression	Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Erythrocyte Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Autosome Genomic Imprinting Regulation Of Cell Development DNA Binding Cell Population Proliferation Regulation Of Epithelial Cell Differentiation Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation NLRP1 Inflammasome Complex Assembly Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Histone Binding Interleukin-7-mediated Signaling Pathway ISGF3 Complex Negative Regulation By Virus Of Viral Protein Levels In Host Cell Interleukin-27-mediated Signaling Pathway Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal Cell Differentiation Involved In Kidney Development Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Negative Regulation Of Developmental Process Nucleoplasm Regulation Of Inner Ear Auditory Receptor Cell Differentiation Cell Proliferation Involved In Kidney Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Nephron Tubule Epithelial Cell Differentiation Protein K29-linked Ubiquitination Regulation Of Developmental Process Negative Regulation Of Astrocyte Differentiation Cellular Response To UV-B Type II Interferon-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity Positive Regulation Of Gene Expression
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