NDEL1 and NDC80

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NDEL1	NDC80
Gene Name		nudE neurodevelopment protein 1-like 1	NDC80 kinetochore complex component
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nucleolus Cytoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding Oligopeptidase Activity	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axon Cargo Transport Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Activation Of Cdc42 GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Neuron Projection Extension	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AIMP2 ANK2 APP BMI1 CCDC88A CCHCR1 CCSER1 CCSER2 CDK5 CENPF CEP170 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 GOLGA2 IMMT KALRN KIFC3 KRT40 LUC7L2 MAGEA11 MBIP MIS18A MLLT10 MRC2 MTUS2 NDC80 NDE1 PAFAH1B1 PKP2 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TRIM27 USP2 XPA YWHAE YWHAG ZNF10 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF260 ZNF264 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF844 ZNF91	45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT
Entrez ID		81565	10403
HPRD ID		06340	06277
Ensembl ID		ENSG00000166579	ENSG00000080986
Uniprot IDs		Q9GZM8	A8K031 O14777
PDB IDs		2V66	2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Cerebral Cortex Development Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Cell Division Pallium Development Cell Cycle Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Telencephalon Development Organelle Organization Cytoskeleton Organization Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Neural Precursor Cell Proliferation Microtubule-based Process Microtubule Cytoskeleton Organization Forebrain Development Regulation Of Gene Expression Cellular Process Cerebral Cortex Radially Oriented Cell Migration Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Regulation Of Heart Rate By Cardiac Conduction Organelle Localization Brain Development Neuron Migration Head Development Cerebral Cortex Cell Migration Movement Of Cell Or Subcellular Component Cell Cycle Process Mitotic Nuclear Division Establishment Of Organelle Localization Telencephalon Cell Migration Cardiac Muscle Cell Action Potential Forebrain Cell Migration Cellular Localization	Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle
Tagcloud ?		ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule organization pilocarpine schizophrenia se seizure spontaneous vessels	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?		mitosis