NDEL1 and KIF19

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		NDEL1	KIF19
Description		nudE neurodevelopment protein 1 like 1	kinesin family member 19
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Synaptic Vesicle Axon Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Axon Cytoplasm	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Cilium Axoneme Cell Projection
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Beta-tubulin Binding	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Neuron Migration Inner Cell Mass Cell Proliferation Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Cell Differentiation Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Vesicle Transport Along Microtubule Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Ruffle Assembly Neuron Projection Extension	Microtubule-based Movement Axonemal Microtubule Depolymerization Plus-end Specific Microtubule Depolymerization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS
Interacting Genes		85 interacting genes: ABI3 ACTB AIMP2 AKAP9 ANK2 APP BMI1 BORCS6 BRK1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 LUC7L2 MAGEA11 MBIP MED11 MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PARVG PICK1 PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TUBB USP2 XPA YWHAE YWHAG ZC2HC1C ZNF10 ZNF12 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF250 ZNF260 ZNF264 ZNF3 ZNF35 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF662 ZNF707 ZNF844 ZNF91	5 interacting genes: AKAP9 HTR2B MAPRE3 NDEL1 RBM5
Entrez ID		81565	124602
HPRD ID		06340	08782
Ensembl ID		ENSG00000166579	ENSG00000196169
Uniprot IDs		A6NIZ0 Q9GZM8	Q2TAC6
PDB IDs		2V66
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Cytoskeleton Microtubule Cell Division Kinesin Complex Microtubule Binding Microtubule Cytoskeleton Organization Cytoskeleton Organization Centrosome Nucleus Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of RNA Biosynthetic Process DNA Binding Cytoskeleton-dependent Intracellular Transport Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Maintenance Of Location In Cell Organelle Organization Kinesin Binding Maintenance Of Location Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasmic Microtubule Organization Organelle Localization Acetylcholine Receptor Activator Activity Microtubule-based Movement Regulation Of Heart Rate By Cardiac Conduction Metal Ion Binding Establishment Of Organelle Localization Regulation Of Cell Cycle Microtubule Organizing Center Organization Central Region Of Growth Cone Protein Binding Cardiac Conduction Protein Kinase C Binding Retrograde Axonal Transport Presynapse Kinetochore Supramolecular Fiber Organization Maintenance Of Protein Location In Cell Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Motor Activity	Microtubule Organizing Center Microtubule Nucleation Centrosome Localization Regulation Of Microtubule Polymerization Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Or Depolymerization Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Maintenance Of Centrosome Location Regulation Of Microtubule Cytoskeleton Organization Potassium Channel Activator Activity Cytoskeleton Organization Dendritic Branch Extrinsic Component Of Postsynaptic Density Membrane Microtubule-based Process Mitotic Spindle Astral Microtubule End Microtubule End Radial Glia-guided Pyramidal Neuron Migration Neurofilament Cytoskeleton Mitotic Centrosome Separation Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Microtubule-based Process Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Microtubule Binding Neuron To Neuron Synapse Axon Hillock Positive Regulation Of Cellular Component Organization Potassium Channel Complex Serotonin Binding Serotonin Receptor Signaling Pathway Neurofilament Cytoskeleton Organization Positive Regulation Of Phospholipid Biosynthetic Process Chemical Synaptic Transmission Serotonin Receptor Activity Neural Crest Cell Differentiation Centrosome Separation G Protein-coupled Serotonin Receptor Activity Trans-synaptic Signaling Synaptic Signaling Protein Localization To Microtubule Microtubule Positive Regulation Of Ruffle Assembly Positive Regulation Of Cell Projection Organization Inner Cell Mass Cell Proliferation Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity Regulation Of Golgi Organization Cytoskeleton
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