NDEL1 and TACC3

Number of citations of the paper that reports this interaction (PMID 17060449)
40

Data Source:
BioGRID (pull down, pull down)

		NDEL1	TACC3
Gene Name		nudE neurodevelopment protein 1-like 1	transforming, acidic coiled-coil containing protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nucleolus Cytoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton	Cytoplasm Centrosome
	Molecular Function	Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding Oligopeptidase Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axon Cargo Transport Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Activation Of Cdc42 GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Neuron Projection Extension	Microtubule Cytoskeleton Organization Response To Hypoxia Cell Proliferation Cerebral Cortex Development Neurogenesis Interkinetic Nuclear Migration Hemopoiesis Astral Microtubule Organization Regulation Of Microtubule-based Process Cytoplasmic Sequestering Of Transcription Factor Regulation Of Cell Cycle
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)
Protein-Protein Interactions		58 interactors: AIMP2 ANK2 APP BMI1 CCDC88A CCHCR1 CCSER1 CCSER2 CDK5 CENPF CEP170 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 GOLGA2 IMMT KALRN KIFC3 KRT40 LUC7L2 MAGEA11 MBIP MIS18A MLLT10 MRC2 MTUS2 NDC80 NDE1 PAFAH1B1 PKP2 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TRIM27 USP2 XPA YWHAE YWHAG ZNF10 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF260 ZNF264 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF844 ZNF91	13 interactors: AKAP9 ARNT2 ASPSCR1 AURKA CDH1 CIB3 KAT2A KIZ NDEL1 SNX20 TBC1D22B TTF2 VPS37C
Entrez ID		81565	10460
HPRD ID		06340	05601
Ensembl ID		ENSG00000166579	ENSG00000013810
Uniprot IDs		Q9GZM8	Q9Y6A5
PDB IDs		2V66
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Cerebral Cortex Development Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Cell Division Pallium Development Cell Cycle Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Telencephalon Development Organelle Organization Cytoskeleton Organization Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Neural Precursor Cell Proliferation Microtubule-based Process Microtubule Cytoskeleton Organization Forebrain Development Regulation Of Gene Expression Cellular Process Cerebral Cortex Radially Oriented Cell Migration Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Regulation Of Heart Rate By Cardiac Conduction Organelle Localization Brain Development Neuron Migration Head Development Cerebral Cortex Cell Migration Movement Of Cell Or Subcellular Component Cell Cycle Process Mitotic Nuclear Division Establishment Of Organelle Localization Telencephalon Cell Migration Cardiac Muscle Cell Action Potential Forebrain Cell Migration Cellular Localization	Mitotic Centrosome Separation Centrosome Separation Positive Regulation Of Metabolic Process Centrosome Localization In Utero Embryonic Development Cell Cycle Process Embryo Development Mitotic Cell Cycle Process Centrosome Cycle Cell Cycle Neuron Projection Extension Mitotic Cell Cycle Brain Development Mitotic Nuclear Division Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Head Development Negative Regulation Of Spindle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Membrane Organization Developmental Cell Growth Positive Regulation Of Cellular Metabolic Process Centrosome Organization Spindle Assembly Involved In Female Meiosis I Pharynx Development Central Nervous System Development Blastocyst Development Microtubule Cytoskeleton Organization Forebrain Development Microtubule Organizing Center Organization Spindle Assembly Involved In Meiosis Epithelium Development Growth Protein Localization G2/M Transition Of Mitotic Cell Cycle Spindle Organization System Development Organ Development Spindle Stabilization Developmental Growth Involved In Morphogenesis Regulation Of Protein Stability Digestive Tract Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Growth Organelle Organization Cellular Response To Indole-3-methanol Histone H3-K14 Acetylation Positive Regulation Of Cellular Protein Catabolic Process Digestive System Development Positive Regulation Of Axon Regeneration
Tagcloud ?		ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels	acidic activating arrest centrosomal centrosome coil coiled death depletion details disrupting diverse g1 integrity lacking member p21 p38 p53 pharmacologically phosphorylated poorly require serine transforming triggered triggering tubulin vertebrates
Tagcloud (Difference) ?		ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels	acidic activating arrest centrosomal centrosome coil coiled death depletion details disrupting diverse g1 integrity lacking member p21 p38 p53 pharmacologically phosphorylated poorly require serine transforming triggered triggering tubulin vertebrates
Tagcloud (Intersection) ?