MLLT10 and HPCA

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MLLT10	HPCA
Name		MLLT10 histone lysine methyltransferase DOT1L cofactor	hippocalcin
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Histone Binding Metal Ion Binding	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate
GWAS		Adult body size ( 32376654 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 23535729 ) Epithelial ovarian cancer ( 25581431 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) Gallstone disease ( 30504769 ) Hand grip strength ( 29691431 ) Lateral ventricular volume in normal aging ( 30258056 ) Meningioma ( 21804547 ) Metabolic syndrome ( 31589552 ) Multiple sclerosis ( 31604244 ) Multisite chronic pain ( 31194737 33830993 ) Oily fish consumption ( 32066663 ) Ovarian cancer ( 23535730 ) Pork consumption ( 32066663 ) Raw vegetable consumption ( 32066663 ) Smoking initiation ( 33082346 ) Subcutaneous adipose tissue ( 26480920 ) Urinary albumin-to-creatinine ratio ( 31630189 ) Urinary sodium excretion ( 31409800 ) Walking pace ( 33128006 )	Daytime nap ( 33568662 )
Novel Interactors		None recorded	12 novel interactors: APC BMP8B CSF3R DPYD E2F2 NDC80 NUDC RAE1 RUNX3 TMEM54 TNFRSF8 TUBA4A
Interacting Genes		16 interacting genes: DISC1 DOT1L EPS15 FOXI1 HNF1B HPCA MLLT1 NCALD NDEL1 POU2F1 POU6F2 RBPMS RGPD5 SS18 VEZF1 YEATS4	17 interacting genes: AP2B1 C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2
Entrez ID		8028	3208
HPRD ID		03874	00811
Ensembl ID		ENSG00000078403	ENSG00000121905
Uniprot IDs		P55197 Q59EQ6	P84074
PDB IDs		5DAG 5DAH 6CKN 6CKO 6JN2 7MJU	5G4P 5G58 5M6C 7OWM
GO Terms Enriched among Interactors		Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cerebral Cortex Radially Oriented Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Cerebral Cortex Cell Migration Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Electrical Stimulus Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Telencephalon Cell Migration Forebrain Cell Migration Kinesin Complex Alpha-tubulin Binding Histone H3K79 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Response To Ketamine Hepatoblast Differentiation Regulation Of Pronephros Size Histone H3K18ac Reader Activity Neurofilament Cytoskeleton Regulation Of Stem Cell Population Maintenance Transcription Coactivator Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Histone H3K27ac Reader Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of Gene Expression	Phosphocreatine Biosynthetic Process Creatine Kinase Activity