NDEL1 and CCDC88A

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		NDEL1	CCDC88A
Description		nudE neurodevelopment protein 1 like 1	coiled-coil and HOOK domain protein 88A
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Synaptic Vesicle Axon Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Axon Cytoplasm	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cell Leading Edge Cytoplasmic Vesicle Ciliary Basal Body Cell Projection
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Beta-tubulin Binding	G-protein Alpha-subunit Binding Actin Binding Protein Kinase C Binding Guanyl-nucleotide Exchange Factor Activity GDP-dissociation Inhibitor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Microtubule Binding Phosphatidylinositol Binding SH2 Domain Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Kinase B Binding Protein Serine/threonine Kinase Activator Activity Dynein Light Intermediate Chain Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Neuron Migration Inner Cell Mass Cell Proliferation Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Cell Differentiation Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Vesicle Transport Along Microtubule Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Ruffle Assembly Neuron Projection Extension	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Cell Migration Cell Projection Organization Lamellipodium Assembly Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization TOR Signaling Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Population Proliferation Positive Regulation Of Cilium Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Organization Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Localization To Cilium
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	RND3 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Height ( 21998595) Periventricular white matter hyperintensities ( 32517579) Refractive error ( 32231278)
Interacting Genes		85 interacting genes: ABI3 ACTB AIMP2 AKAP9 ANK2 APP BMI1 BORCS6 BRK1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 LUC7L2 MAGEA11 MBIP MED11 MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PARVG PICK1 PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TUBB USP2 XPA YWHAE YWHAG ZC2HC1C ZNF10 ZNF12 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF250 ZNF260 ZNF264 ZNF3 ZNF35 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF662 ZNF707 ZNF844 ZNF91	13 interacting genes: AKT1 BRAF CTNNA2 CTNNB1 DISC1 EGFR EXOC1 GNAI3 INSR KDR NDEL1 PRKACA PTPN6
Entrez ID		81565	55704
HPRD ID		06340	11131
Ensembl ID		ENSG00000166579	ENSG00000115355
Uniprot IDs		A6NIZ0 Q9GZM8	O14997 Q3V6T2
PDB IDs		2V66	6MHF
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Cytoskeleton Microtubule Cell Division Kinesin Complex Microtubule Binding Microtubule Cytoskeleton Organization Cytoskeleton Organization Centrosome Nucleus Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of RNA Biosynthetic Process DNA Binding Cytoskeleton-dependent Intracellular Transport Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Maintenance Of Location In Cell Organelle Organization Kinesin Binding Maintenance Of Location Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasmic Microtubule Organization Organelle Localization Acetylcholine Receptor Activator Activity Microtubule-based Movement Regulation Of Heart Rate By Cardiac Conduction Metal Ion Binding Establishment Of Organelle Localization Regulation Of Cell Cycle Microtubule Organizing Center Organization Central Region Of Growth Cone Protein Binding Cardiac Conduction Protein Kinase C Binding Retrograde Axonal Transport Presynapse Kinetochore Supramolecular Fiber Organization Maintenance Of Protein Location In Cell Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Motor Activity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Ciliary Basal Body Cell Surface Receptor Signaling Pathway Phosphorylation Regulation Of Macroautophagy ERBB Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Protein Kinase Activity Animal Organ Morphogenesis Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Growth Factor Stimulus Cell Migration Cerebral Cortex Cell Migration Positive Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Kinase Activity Regulation Of Cell Differentiation Cell Motility Regulation Of MAPK Cascade Telencephalon Cell Migration Positive Regulation Of D-glucose Transmembrane Transport Embryonic Organ Development Forebrain Cell Migration Positive Regulation Of Glucose Metabolic Process Regulation Of Autophagy Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Radial Glia-guided Pyramidal Neuron Migration Regulation Of Developmental Process Identical Protein Binding Signal Transduction Regulation Of Neuron Projection Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Positive Regulation Of MAPK Cascade
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