MLLT10 and YEATS4

Number of citations of the paper that reports this interaction (PMID 11756182)
20

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		MLLT10	YEATS4
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	YEATS domain containing 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleoplasm Nucleolus Cytoplasm Nuclear Matrix NuA4 Histone Acetyltransferase Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Chromatin Organization Transcription, DNA-templated Mitotic Nuclear Division Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Meningioma ( 21804547) Ovarian cancer ( 23535730)	Height ( 18391951) Response to diuretic therapy ( 18591461)
Protein-Protein Interactions		7 interactors: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4	14 interactors: CEP162 FRMD4A KDM1A MLLT10 MRGBP MYC MYCN NUMA1 PFDN1 RNF8 SMARCB1 TACC1 TACC2 TFAP2B
Entrez ID		8028	8089
HPRD ID		03874	03666
Ensembl ID		ENSG00000078403	ENSG00000127337
Uniprot IDs		P55197 Q59EQ6 Q6N002	F8W0J4 O95619
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebral Cortex Radially Oriented Cell Migration Microtubule Cytoskeleton Organization Cerebral Cortex Cell Migration Histone H3-K79 Methylation Telencephalon Cell Migration Forebrain Cell Migration Organelle Organization Cerebral Cortex Development Neuron Migration Microtubule-based Process Pallium Development Positive Regulation Of Axon Regeneration Retrograde Axon Cargo Transport Peptidyl-lysine Modification Positive Regulation Of Neuron Projection Regeneration Activation Of Cdc42 GTPase Activity Mitotic Centrosome Separation Telencephalon Development Neurofilament Cytoskeleton Organization Cytoskeleton Organization Centrosome Separation Mitotic Nuclear Division Regulation Of Axon Regeneration Histone H2A Acetylation Positive Regulation Of Cdc42 GTPase Activity Regulation Of Metabolic Process Regulation Of Neuron Projection Development Mitochondrial Calcium Ion Homeostasis Histone Modification Inner Cell Mass Cell Proliferation Positive Regulation Of Neurogenesis Regulation Of Synapse Maturation Neuronal Stem Cell Maintenance Microtubule Nucleation TOR Signaling Forebrain Development Protein Targeting To Golgi Regulation Of Cdc42 GTPase Activity Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription Regulatory Region DNA Binding Blastocyst Growth Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Centrosome Localization	Organelle Organization Cell Cycle Anatomical Structure Development Positive Regulation Of Stem Cell Proliferation System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Interkinetic Nuclear Migration Chromatin Organization Regulation Of Stem Cell Proliferation Multicellular Organismal Development Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Organ Development Forebrain Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nervous System Development Chromatin Remodeling Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Organization Cell Cycle Process Regulation Of RNA Metabolic Process Cell Differentiation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Mesenchymal Cell Proliferation Nucleus Localization Cell Proliferation In Forebrain Regulation Of Mesenchymal Cell Proliferation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Telencephalon Development Tube Development Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Cellular Creatinine Homeostasis Cellular Urea Homeostasis Cellular Ammonia Homeostasis Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Response To DNA Damage Stimulus ATP-dependent Chromatin Remodeling Brain Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Head Development Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation
Tagcloud ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 nkx2 normalization normalizations obtaining perturbations pipelines plag1 ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	12q13 abrogated amplified attenuation bronchial candidate cisplastin cleavage colony contributing conversely copy define helped identifying impairing implicating inducing integrative matched nsclc oncogene oncogenes overexpressed p21waf1 parp reveal rnai senescence
Tagcloud (Difference) ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 nkx2 normalization normalizations obtaining perturbations pipelines plag1 ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	12q13 abrogated amplified attenuation bronchial candidate cisplastin cleavage colony contributing conversely copy define helped identifying impairing implicating inducing integrative matched nsclc oncogene oncogenes overexpressed p21waf1 parp reveal rnai senescence
Tagcloud (Intersection) ?