SNRNP70 and CFAP298

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SNRNP70	CFAP298
Description		small nuclear ribonucleoprotein U1 subunit 70	cilia and flagella associated protein 298
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck Lysosomal Lumen U2-type Prespliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding U1 SnRNA Binding U1 SnRNP Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chaperone-mediated Autophagy	Regulation Of Cilium Movement Cilium Assembly
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653) Venous thromboembolism ( 33592630)
Interacting Genes		67 interacting genes: ADARB1 APP ARSF BACE2 CASP3 CBS CDC42 CDKL3 CEBPA CEP63 CFAP298 CHERP CRP CTDP1 DDX17 DYRK1A FTCD GATD3 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 HUNK IL32 IL7R ITSN1 LRP1 MYC NUDT21 OGT PDE9A PIGP PRKD2 PRMT5 PRPF40A PRPF6 PSMG1 RASGRF1 RBM11 RELA RIPPLY3 RNF11 RSPH1 RUNX1 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SPATC1L SRPK1 SRRM4 SRSF1 SRSF10 SRSF2 SUMO3 TIAM1 USP25 USP7 WBP4 ZRANB2	21 interacting genes: APP COPS5 ERBB2 EWSR1 FMN2 GMCL1 KPNA4 MAPK6 NCOA2 PAX6 PTGER4 RANBP9 RFX5 RPH3A SNRNP70 SPTBN4 TAF1 TRPS1 UNC13B ZNF521 ZNF624
Entrez ID		6625	56683
HPRD ID		01617	10756
Ensembl ID		ENSG00000104852	ENSG00000159079
Uniprot IDs		P08621 Q9UFS1	C9J818 D3DSE6 P57076
PDB IDs		2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9 7B0Y 7VPX 8R08
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex MRNA Processing Heteromeric SMAD Protein Complex RNA Metabolic Process RNA Processing RNA Splicing Nucleoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process I-SMAD Binding Regulation Of MRNA Splicing, Via Spliceosome SMAD Protein Signal Transduction RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Growth Factor Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Positive Regulation Of Developmental Process Identical Protein Binding Embryonic Pattern Specification Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cardiac Conduction System Development Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Transcription Spliceosomal SnRNP Assembly Nuclear Speck Positive Regulation Of Cell Differentiation Spliceosomal Complex Assembly Protein-containing Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression DEAD/H-box RNA Helicase Binding RNA Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process	Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Regulation Of Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Axonogenesis Neuromuscular Junction Development Nucleoplasm Secretion By Cell Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Neuron Fate Commitment Establishment Of Organelle Localization Negative Regulation Of Eosinophil Extravasation Positive Regulation Of Androgen Receptor Signaling Pathway Transcription Regulator Inhibitor Activity Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Priming Homologous Chromosome Movement Towards Spindle Pole In Meiosis I Anaphase Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Locomotory Behavior MRNA Transcription By RNA Polymerase II Establishment Of Localization In Cell Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process
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