SNRNP70 and DDX17

Number of citations of the paper that reports this interaction (PubMedID 12193588)
0

Data Source:
HPRD (in vivo)

		SNRNP70	DDX17
Description		small nuclear ribonucleoprotein U1 subunit 70	DEAD-box helicase 17
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck Lysosomal Lumen U2-type Prespliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding U1 SnRNA Binding U1 SnRNP Binding	Nucleotide Binding Nucleic Acid Binding Transcription Coactivator Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chaperone-mediated Autophagy	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Epithelial To Mesenchymal Transition Immune System Process Regulation Of Transcription By RNA Polymerase II RRNA Processing RNA Processing MRNA Processing RNA Splicing MiRNA Metabolic Process Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Skeletal Muscle Cell Differentiation
Pathways		mRNA Splicing - Major Pathway	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653) Venous thromboembolism ( 33592630)	Hip index ( 34021172) Menopause (age at onset) ( 26414677) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		67 interacting genes: ADARB1 APP ARSF BACE2 CASP3 CBS CDC42 CDKL3 CEBPA CEP63 CFAP298 CHERP CRP CTDP1 DDX17 DYRK1A FTCD GATD3 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 HUNK IL32 IL7R ITSN1 LRP1 MYC NUDT21 OGT PDE9A PIGP PRKD2 PRMT5 PRPF40A PRPF6 PSMG1 RASGRF1 RBM11 RELA RIPPLY3 RNF11 RSPH1 RUNX1 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SPATC1L SRPK1 SRRM4 SRSF1 SRSF10 SRSF2 SUMO3 TIAM1 USP25 USP7 WBP4 ZRANB2	49 interacting genes: APBB1 APP BYSL CCDC187 CEBPA CREBBP CSNK2A1 DDX5 DDX6 DRC4 EGFR ESR1 FBL FOXP1 FXR2 GRB2 HADHB HDAC1 HNRNPH1 HNRNPH3 HNRNPK LNX1 NCOA1 NCOA2 NCOA3 OGT PIN1 PRPF6 PTK6 PTPRD RBM10 RBM14 RBM15 RBM4 RBM5 RBM7 SF1 SF3B4 SFPQ SNCA SNRNP70 SNRPA SORBS3 SREK1 SUMO2 USP7 WBP11 WBP2 YWHAG
Entrez ID		6625	10521
HPRD ID		01617	10532
Ensembl ID		ENSG00000104852	ENSG00000100201
Uniprot IDs		P08621 Q9UFS1	A0A5H1ZRQ2 Q59F66 Q92841
PDB IDs		2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9 7B0Y 7VPX 8R08	6UV0 6UV1 6UV2 6UV3 6UV4
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex MRNA Processing Heteromeric SMAD Protein Complex RNA Metabolic Process RNA Processing RNA Splicing Nucleoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process I-SMAD Binding Regulation Of MRNA Splicing, Via Spliceosome SMAD Protein Signal Transduction RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Growth Factor Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Positive Regulation Of Developmental Process Identical Protein Binding Embryonic Pattern Specification Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cardiac Conduction System Development Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Transcription Spliceosomal SnRNP Assembly Nuclear Speck Positive Regulation Of Cell Differentiation Spliceosomal Complex Assembly Protein-containing Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression DEAD/H-box RNA Helicase Binding RNA Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process	Nucleoplasm MRNA Metabolic Process RNA Splicing RNA Binding RNA Metabolic Process Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Spliceosomal Complex Regulation Of RNA Splicing RNA Processing Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Regulation Of MRNA Processing Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II MRNA Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Nuclear Speck Chromatin Remodeling Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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