SNRNP70 and ZRANB2

Number of citations of the paper that reports this interaction (PubMedID 11448987)
58

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SNRNP70	ZRANB2
Description		small nuclear ribonucleoprotein U1 subunit 70	zinc finger RANBP2-type containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck Lysosomal Lumen U2-type Prespliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding U1 SnRNA Binding U1 SnRNP Binding	Lipopolysaccharide Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chaperone-mediated Autophagy	RNA Processing MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653) Venous thromboembolism ( 33592630)	Dental caries (decayed, missing and filled teeth) ( 31533690) Verbal declarative memory ( 25648963)
Interacting Genes		67 interacting genes: ADARB1 APP ARSF BACE2 CASP3 CBS CDC42 CDKL3 CEBPA CEP63 CFAP298 CHERP CRP CTDP1 DDX17 DYRK1A FTCD GATD3 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 HUNK IL32 IL7R ITSN1 LRP1 MYC NUDT21 OGT PDE9A PIGP PRKD2 PRMT5 PRPF40A PRPF6 PSMG1 RASGRF1 RBM11 RELA RIPPLY3 RNF11 RSPH1 RUNX1 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SPATC1L SRPK1 SRRM4 SRSF1 SRSF10 SRSF2 SUMO3 TIAM1 USP25 USP7 WBP4 ZRANB2	17 interacting genes: AKAP17A CEBPA CSNK2A1 EP300 KIF20A LRRK2 OGT SMN1 SNRNP70 SREK1 SRPK1 SRPK2 SRSF2 TRA2B U2AF1 UBC YY1
Entrez ID		6625	9406
HPRD ID		01617	09185
Ensembl ID		ENSG00000104852	ENSG00000132485
Uniprot IDs		P08621 Q9UFS1	O95218
PDB IDs		2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9 7B0Y 7VPX 8R08	1N0Z 2K1P 3G9Y
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex MRNA Processing Heteromeric SMAD Protein Complex RNA Metabolic Process RNA Processing RNA Splicing Nucleoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process I-SMAD Binding Regulation Of MRNA Splicing, Via Spliceosome SMAD Protein Signal Transduction RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Growth Factor Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Positive Regulation Of Developmental Process Identical Protein Binding Embryonic Pattern Specification Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cardiac Conduction System Development Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Transcription Spliceosomal SnRNP Assembly Nuclear Speck Positive Regulation Of Cell Differentiation Spliceosomal Complex Assembly Protein-containing Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression DEAD/H-box RNA Helicase Binding RNA Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process	RNA Splicing MRNA Metabolic Process MRNA Processing RNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Macromolecule Metabolic Process RNA Binding Regulation Of RNA Splicing RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Spliceosomal Complex Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Nucleic Acid Binding Spliceosomal Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process RNA Splicing, Via Transesterification Reactions STAT Family Protein Binding Regulation Of RNA Metabolic Process Chromatin DNA Binding Negative Regulation Of Autophagy Regulation Of Nucleobase-containing Compound Metabolic Process Sin3-type Complex Negative Regulation Of Protein Catabolic Process Regulation Of Gene Expression Histone Acetyltransferase Complex Nuclear Matrix Protein Kinase A Binding Regulation Of Macromolecule Biosynthetic Process PcG Protein Complex Protein Serine Kinase Activity Negative Regulation Of Proteolysis Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macrophage Activation Regulation Of Primary Metabolic Process Positive Regulation Of Viral Genome Replication Regulation Of Autophagy Regulation Of Proteolysis Protein Serine/threonine Kinase Activity Hemopoiesis Positive Regulation Of Proteolysis
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