ZC3H12A and KPNA2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ZC3H12A	KPNA2
Gene Name		zinc finger CCCH-type containing 12A	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Endonuclease Activity Protein Binding Metal Ion Binding	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding
	Biological Process	Angiogenesis Apoptotic Process Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Lipid Storage Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Cellular Response To Lipopolysaccharide Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway
Pathways			ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AHSP AIMP2 BTRC CYFIP2 EP300 IKBKG IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK UBC	104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		80149	3838
HPRD ID		08021	02818
Ensembl ID		ENSG00000163874	ENSG00000182481
Uniprot IDs		Q5D1E8	P52292 Q7Z726
PDB IDs		3V32 3V33 3V34	1EFX 1QGK 1QGR 3FEX 3FEY 4E4V
Enriched GO Terms of Interacting Partners?		I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Viral Process Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response-activating Signal Transduction Regulation Of Protein Stability Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response Regulation Of Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Apoptotic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of Type I Interferon Production JNK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Protein Stabilization Regulation Of Type I Interferon Production Regulation Of Immune System Process Positive Regulation Of Cytokine Production Stress-activated MAPK Cascade G2/M Transition Of Mitotic Cell Cycle Stress-activated Protein Kinase Signaling Cascade Defense Response	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development
Tagcloud ?		attached attenuating cascade ccch chains chemotactic consequences consistently deleterious deubiquitinase deubiquitination elucidated feedback finger genotoxic kappab linear mcpip1 mediating monocyte nemo polyubiquitin promotion serves signalling terminated ubiquitylation uncontrolled usp10	aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus
Tagcloud (Difference) ?		attached attenuating cascade ccch chains chemotactic consequences consistently deleterious deubiquitinase deubiquitination elucidated feedback finger genotoxic kappab linear mcpip1 mediating monocyte nemo polyubiquitin promotion serves signalling terminated ubiquitylation uncontrolled usp10	aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus
Tagcloud (Intersection) ?