ZC3H12A and SHBG

Number of citations of the paper that reports this interaction (PMID 15862967)
1

Data Source:
HPRD (two hybrid)

		ZC3H12A	SHBG
Gene Name		zinc finger CCCH-type containing 12A	sex hormone-binding globulin
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Endonuclease Activity Protein Binding Metal Ion Binding	Androgen Binding
	Biological Process	Angiogenesis Apoptotic Process Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Lipid Storage Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Cellular Response To Lipopolysaccharide Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Reactive Oxygen Species Metabolic Process	Primary Spermatocyte Growth
Pathways
Drugs
Diseases
GWAS			Androgen levels ( 22936694) Protein quantitative trait loci ( 18464913) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597)
Protein-Protein Interactions		13 interactors: AHSP AIMP2 BTRC CYFIP2 EP300 IKBKG IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK UBC	62 interactors: A2M ACPP ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5A1 AZGP1 C9orf24 CD177 CECR5 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		80149	6462
HPRD ID		08021	01646
Ensembl ID		ENSG00000163874	ENSG00000129214
Uniprot IDs		Q5D1E8	B0FWH2 B4DYU0 I3L1J1 I3L2X4 P04278
PDB IDs		3V32 3V33 3V34	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW
Enriched GO Terms of Interacting Partners?		I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Viral Process Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response-activating Signal Transduction Regulation Of Protein Stability Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response Regulation Of Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Apoptotic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of Type I Interferon Production JNK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Protein Stabilization Regulation Of Type I Interferon Production Regulation Of Immune System Process Positive Regulation Of Cytokine Production Stress-activated MAPK Cascade G2/M Transition Of Mitotic Cell Cycle Stress-activated Protein Kinase Signaling Cascade Defense Response	Platelet Activation Extracellular Matrix Disassembly Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Zinc Ion Endocytosis Vesicle-mediated Transport Response To Wounding Transport Endosomal Transport Cell Activation Response To Zinc Ion Cell Projection Organization Immune System Process MRNA Transcription From RNA Polymerase II Promoter Glucose Metabolic Process MRNA Transcription Neuron Projection Development Movement Of Cell Or Subcellular Component Cellular Response To Cadmium Ion Regulation Of Water Loss Via Skin Formation Of Translation Preinitiation Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Morphogenesis Involved In Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Hexose Metabolic Process Neuron Development Extracellular Matrix Organization Viral Process Cytoplasmic Sequestering Of Protein Regulation Of Defense Response To Virus By Virus Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axon Development Antigen Processing And Presentation Of Peptide Antigen Locomotion Negative Regulation Of Growth Monosaccharide Metabolic Process Sperm Entry Negative Regulation Of T Cell Migration Contractile Actin Filament Bundle Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Positive Regulation Of Late Endosome To Lysosome Transport Sorbitol Catabolic Process L-xylitol Metabolic Process L-xylitol Catabolic Process Fructose Biosynthetic Process
Tagcloud ?		attached attenuating cascade ccch chains chemotactic consequences consistently deleterious deubiquitinase deubiquitination elucidated feedback finger genotoxic kappab linear mcpip1 mediating monocyte nemo polyubiquitin promotion serves signalling terminated ubiquitylation uncontrolled usp10	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Difference) ?		attached attenuating cascade ccch chains chemotactic consequences consistently deleterious deubiquitinase deubiquitination elucidated feedback finger genotoxic kappab linear mcpip1 mediating monocyte nemo polyubiquitin promotion serves signalling terminated ubiquitylation uncontrolled usp10	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Intersection) ?