SYNPO2L and SH3RF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYNPO2L	SH3RF1
Description		synaptopodin 2 like	SH3 domain containing ring finger 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Z Disc Organelle	Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Heart Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Rho Protein Signal Transduction Sarcomere Organization Positive Regulation Of Stress Fiber Assembly	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 22544366 28416818 29290336 29892015 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Incident atrial fibrillation ( 28416818) Mean arterial pressure ( 27618448) PR interval ( 32439900) Systolic blood pressure ( 27618452)	Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)
Interacting Genes		7 interacting genes: ACTN1 ACTN2 ACTN3 GOLGA2 PSMB4 SH3RF1 SORBS3	69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1
Entrez ID		79933	57630
HPRD ID		15457	15335
Ensembl ID		ENSG00000166317	ENSG00000154447
Uniprot IDs		Q9H987	Q7Z6J0
PDB IDs			7NZC 7NZD
Enriched GO Terms of Interacting Partners?		Pseudopodium Focal Adhesion Assembly Cell-substrate Junction Organization Cell-substrate Junction Assembly Sarcomere Cortical Actin Cytoskeleton Actin Filament Muscle Cell Development Vinculin Binding Transmembrane Transporter Binding Cytoskeleton Organization Focal Adhesion Z Disc Integrin Binding Actin Filament Binding Cell Junction Structural Constituent Of Muscle Cell Junction Assembly Actin Cytoskeleton Brush Border Cytoskeletal Protein Binding Platelet Alpha Granule Lumen Actin Cytoskeleton Organization Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Actin Binding Actin Filament-based Process Regulation Of Primary Metabolic Process Structural Constituent Of Postsynapse Titin Z Domain Binding Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Cell Junction Organization Platelet Morphogenesis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Cell Projection Microspike Assembly Positive Regulation Of Protein Glycosylation Organelle Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cytoskeleton Calcium Ion Binding Actin Filament Network Formation Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Positive Regulation Of Cytoskeleton Organization FATZ Binding	SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm
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