SYNPO2L and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYNPO2L	SORBS3
Description		synaptopodin 2 like	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Z Disc Organelle	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction
	Molecular Function	Actin Binding Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding
	Biological Process	Heart Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Rho Protein Signal Transduction Sarcomere Organization Positive Regulation Of Stress Fiber Assembly	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS		Atrial fibrillation ( 22544366 28416818 29290336 29892015 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Incident atrial fibrillation ( 28416818) Mean arterial pressure ( 27618448) PR interval ( 32439900) Systolic blood pressure ( 27618452)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		7 interacting genes: ACTN1 ACTN2 ACTN3 GOLGA2 PSMB4 SH3RF1 SORBS3	137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		79933	10174
HPRD ID		15457	11535
Ensembl ID		ENSG00000166317	ENSG00000120896
Uniprot IDs		Q9H987	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Pseudopodium Focal Adhesion Assembly Cell-substrate Junction Organization Cell-substrate Junction Assembly Sarcomere Cortical Actin Cytoskeleton Actin Filament Muscle Cell Development Vinculin Binding Transmembrane Transporter Binding Cytoskeleton Organization Focal Adhesion Z Disc Integrin Binding Actin Filament Binding Cell Junction Structural Constituent Of Muscle Cell Junction Assembly Actin Cytoskeleton Brush Border Cytoskeletal Protein Binding Platelet Alpha Granule Lumen Actin Cytoskeleton Organization Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Actin Binding Actin Filament-based Process Regulation Of Primary Metabolic Process Structural Constituent Of Postsynapse Titin Z Domain Binding Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Cell Junction Organization Platelet Morphogenesis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Cell Projection Microspike Assembly Positive Regulation Of Protein Glycosylation Organelle Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cytoskeleton Calcium Ion Binding Actin Filament Network Formation Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Positive Regulation Of Cytoskeleton Organization FATZ Binding	Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection
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