HDAC11 and MAPK6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HDAC11	MAPK6
Gene Name		histone deacetylase 11	mitogen-activated protein kinase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Histone Deacetylase Activity Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Oligodendrocyte Development Chromatin Modification Histone Deacetylation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		5 interactors: CDKN1A HDAC6 MAPK6 NELFCD PHYHIP	167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		79885	5597
HPRD ID		09146	04213
Ensembl ID		ENSG00000163517	ENSG00000069956
Uniprot IDs		B5MCQ6 E7ETT9 Q96DB2	Q16659
PDB IDs			2I6L
Enriched GO Terms of Interacting Partners?		Cellular Response To Heat Response To Heat Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Response To Toxic Substance Response To Temperature Stimulus Cellular Response To Extracellular Stimulus Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Intestinal Epithelial Cell Maturation Aggresome Assembly Cellular Response To UV-B Tubulin Deacetylation Positive Regulation Of Oxidative Stress-induced Cell Death Peptidyl-lysine Deacetylation Cellular Response To Misfolded Protein Positive Regulation Of Receptor Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Stress-induced Premature Senescence Response To Misfolded Protein Regulation Of Hydrogen Peroxide-induced Cell Death Response To Extracellular Stimulus Misfolded Or Incompletely Synthesized Protein Catabolic Process Regulation Of Microtubule-based Movement Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Arrest Regulation Of Receptor Biosynthetic Process Response To UV-B Intestinal Epithelial Cell Development Regulation Of Protein Import Into Nucleus, Translocation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Androgen Receptor Signaling Pathway Intestinal Epithelial Cell Differentiation Epithelial Cell Maturation Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Histone H4 Deacetylation Negative Regulation Of Oxidoreductase Activity Response To Arsenic-containing Substance Regulation Of Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Senescence Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Microtubule Depolymerization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated
Tagcloud ?		acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac3 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Difference) ?		acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac3 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Intersection) ?