HDAC11 and CDC25A

Number of citations of the paper that reports this interaction (PubMedID 26967250)
63

Data Source:
BioGRID (enzymatic study)

		HDAC11	CDC25A
Description		histone deacetylase 11	cell division cycle 25A
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Histone Deacetylase Activity Protein Binding Hydrolase Activity DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding Protein-folding Chaperone Binding
	Biological Process	Chromatin Organization Epigenetic Regulation Of Gene Expression	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Cell Population Proliferation Response To Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Replication Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway	Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Body mass index ( 26426971) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Ulcerative colitis ( 26278503) Waist circumference adjusted for body mass index ( 34021172)	A body shape index ( 34021172) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Loneliness (multivariate analysis) ( 27629369) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 27618447) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: CDC25A CDKN1A HDAC6 MAPK6 NELFCD NRM PHYHIP	57 interacting genes: APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDK5 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR EP300 FAM193B FBXW11 FGF21 FTH1 HDAC11 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NAA11 NFKBIB NFYA PEX19 PIM1 PIN1 PKM POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 SRC UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		79885	993
HPRD ID		09146	00305
Ensembl ID		ENSG00000163517	ENSG00000164045
Uniprot IDs		B5MCQ6 Q96DB2	D8KXX0 K7N7S0 P30304
PDB IDs			1C25 8ROZ
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Replication PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Septin Cytoskeleton Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Protein Kinase Binding Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Developmental Growth Tubulin Deacetylation Positive Regulation Of Response To Oxidative Stress Regulation Of Cholangiocyte Proliferation Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Replication Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Oligomerization NELF Complex Regulation Of Reactive Oxygen Species Metabolic Process Mitotic Cell Cycle Phase Transition Type 2 Mitophagy ATPase Inhibitor Activity Erythrocyte Enucleation	Nucleus Cytosol Cytoplasm Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Activity Regulation Of Cell Cycle Kinase Activity Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Nucleobase-containing Compound Metabolic Process MAPK Cascade G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Localization Phosphoserine Residue Binding Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine Kinase Activity Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Signal Transduction Regulation Of Cellular Localization Protein Phosphorylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Regulation Of Intracellular Protein Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Modification Process Regulation Of TORC1 Signaling
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