HDAC11 and PHYHIP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HDAC11	PHYHIP
Description		histone deacetylase 11	phytanoyl-CoA 2-hydroxylase interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Plasma Membrane	Cytoplasm
	Molecular Function	Histone Deacetylase Activity Protein Binding Hydrolase Activity DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Chromatin Organization Epigenetic Regulation Of Gene Expression	Intracellular Protein Localization
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway
Drugs		Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Body mass index ( 26426971) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Ulcerative colitis ( 26278503) Waist circumference adjusted for body mass index ( 34021172)	Hypertriglyceridemia ( 23505323)
Interacting Genes		7 interacting genes: CDC25A CDKN1A HDAC6 MAPK6 NELFCD NRM PHYHIP	24 interacting genes: ADGRB1 COPS6 DYRK1A EEF1A1 ERG28 FAM131A HDAC11 HNRNPA1 MAGED4B MED8 METTL18 NDRG1 NDUFV3 NFE2 PHYH PNPLA2 PPIE PRMT5 S100A13 SMARCC2 SUPT5H TTR WDR89 ZZEF1
Entrez ID		79885	9796
HPRD ID		09146	16345
Ensembl ID		ENSG00000163517	ENSG00000168490
Uniprot IDs		B5MCQ6 Q96DB2	Q92561
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Replication PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Septin Cytoskeleton Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Protein Kinase Binding Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Developmental Growth Tubulin Deacetylation Positive Regulation Of Response To Oxidative Stress Regulation Of Cholangiocyte Proliferation Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Replication Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Oligomerization NELF Complex Regulation Of Reactive Oxygen Species Metabolic Process Mitotic Cell Cycle Phase Transition Type 2 Mitophagy ATPase Inhibitor Activity Erythrocyte Enucleation
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