CACNA1S and RIMS2

Number of citations: 0 (PubMedID 14660679)
Data Source: HPRD (in vitro)

		CACNA1S	RIMS2
Name		calcium voltage-gated channel subunit alpha1 S	regulating synaptic membrane exocytosis 2
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Sarcoplasmic Reticulum T-tubule I Band Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex	Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Extracellular Exosome Presynaptic Active Zone Cytoplasmic Component
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Small Molecule Binding Metal Ion Binding Molecular Function Activator Activity	Protein Binding Zinc Ion Binding Small GTPase Binding Transmembrane Transporter Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Skeletal System Development Extraocular Skeletal Muscle Development Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Striated Muscle Contraction Endoplasmic Reticulum Organization Skeletal Muscle Tissue Development Myoblast Fusion Neuromuscular Junction Development Monoatomic Ion Transmembrane Transport Skeletal Muscle Adaptation Positive Regulation Of Muscle Contraction Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Muscle Cell Development Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Calcium Ion Import Across Plasma Membrane	Intracellular Protein Transport Exocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Synaptic Vesicle Docking Synaptic Vesicle Priming Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Cell Differentiation Regulation Of Membrane Potential Maintenance Of Presynaptic Active Zone Structure Calcium Ion-regulated Exocytosis Of Neurotransmitter Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		NCAM1 interactions	None
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Pinaverium Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil	None
Diseases		Hypokalemic periodic paralysis (HypoPP)	None
GWAS		Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cardiac Troponin-T levels ( 31014085 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 ) Glomerular filtration rate (creatinine) ( 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Inflammatory bowel disease ( 28067908 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Permanent tooth development ( 21931568 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Tooth agenesis ( 29364747 ) Ulcerative colitis ( 28067908 20228799 ) Urinary albumin-to-creatinine ratio ( 31511532 )	Cocaine dependence ( 23958962 ) Dietary fat liking ( 32516399 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) High density lipoprotein cholesterol levels ( 30498476 ) Monoclonal gammopathy of undetermined significance ( 30737484 ) Multiple system atrophy (pathologically confirmed) ( 27629089 ) Parkinson's disease progression (cognitive) ( 33958783 )
Novel Interactors		2 novel interactors: KDR SLC25A17	2 novel interactors: CD44 PABPC1
Interacting Genes		9 interacting genes: CCDC106 CYSRT1 MEOX2 NHERF4 REL RIMS2 RYR1 SRI TNKS	13 interacting genes: ABCA1 CACNA1S EGFR RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH
Entrez ID		779	9699
HPRD ID		00248	09436
Ensembl ID		ENSG00000081248	ENSG00000176406
Uniprot IDs		B1ALM3 Q13698	A0A8Q3SIU4 A0A8Q3SJ53 A0A994J503 A0A994J5M6 A0A994J7W6 F8W6W8 Q9UQ26
PDB IDs		2VAY 6B27	1V27 1WFG
GO Terms Enriched among Interactors		Regulation Of CGMP-mediated Signaling Epithelium Development Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Cell Migration Involved In Sprouting Angiogenesis Sarcoplasmic Reticulum Membrane FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Guanylate Cyclase Inhibitor Activity	Myosin V Binding Exocytosis Secretion By Cell Secretion Regulation Of Exocytosis Establishment Of Protein Localization Synaptic Vesicle Protein Transport GTP-dependent Protein Binding Endosome Positive Regulation Of Regulated Secretory Pathway Regulation Of Transport Vesicle-mediated Transport GTPase Activity Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Intracellular Protein Localization GTP Binding Regulation Of Secretion Positive Regulation Of Exocytosis Positive Regulation Of Transport Nucleotide Binding Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Regulated Secretory Pathway Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Plasma Membrane Membrane Peptide Secretion GDP Binding Presynapse Golgi Apparatus Regulation Of Synaptic Vesicle Cycle Peptide Transport Antigen Processing And Presentation Small GTPase Binding Regulation Of Biological Quality Secretory Granule Regulated Exocytosis Vesicle Organization Intracellular Vesicle Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Perinuclear Region Of Cytoplasm Amide Transport Signal Release Calcium-ion Regulated Exocytosis Regulation Of Vesicle Fusion Synaptic Vesicle Transport