CACNA1S and RYR1

Number of citations of the paper that reports this interaction (PMID 9199552)
43

Data Source:
HPRD (in vivo)

		CACNA1S	RYR1
Gene Name		calcium channel, voltage-dependent, L type, alpha 1S subunit	ryanodine receptor 1 (skeletal)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Sarcoplasmic Reticulum T-tubule I Band	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Junctional Membrane Complex T-tubule I Band Sarcoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Calcium Channel Activity High Voltage-gated Calcium Channel Activity Metal Ion Binding	Protease Binding Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding Calcium-release Channel Activity
	Biological Process	Skeletal System Development Extraocular Skeletal Muscle Development Calcium Ion Transport Muscle Contraction Striated Muscle Contraction Endoplasmic Reticulum Organization Axon Guidance Myoblast Fusion Neuromuscular Junction Development Regulation Of Ion Transmembrane Transport Skeletal Muscle Adaptation Skeletal Muscle Fiber Development Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	Ion channel transport Stimuli-sensing channels
Drugs			Caffeine Dantrolene Suramin
Diseases
GWAS		Permanent tooth development ( 21931568)
Protein-Protein Interactions		4 interactors: PDZD3 RIMS2 RYR1 SRI	12 interactors: CACNA1S CALM1 CAMK2G FKBP1A HOMER1 HOMER2 HOMER3 PRKACA PRKG1 RYR2 S100A1 TRDN
Entrez ID		779	6261
HPRD ID		00248	01618
Ensembl ID		ENSG00000081248	ENSG00000196218
Uniprot IDs		B1ALM3 Q13698	P21817
PDB IDs		2VAY
Enriched GO Terms of Interacting Partners?		Cyclic-nucleotide-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity Second-messenger-mediated Signaling Regulation Of Ion Homeostasis Intracellular Sequestering Of Iron Ion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Membrane Potential Muscle Organ Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transport Regulation Of High Voltage-gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Relaxation Of Muscle Ion Transport Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Cellular Metal Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Regulation Of Ion Transmembrane Transport Transport Cellular Cation Homeostasis Regulation Of Cell Communication By Electrical Coupling Cellular Ion Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Metal Ion Homeostasis Negative Regulation Of Transcription Regulatory Region DNA Binding Muscle Structure Development Heart Development Ossification Involved In Bone Maturation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Chemical Homeostasis Bone Maturation Ion Homeostasis Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Cytoplasmic Sequestering Of Transcription Factor Regulation Of CGMP Biosynthetic Process CAMP-mediated Signaling Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Negative Regulation Of Lyase Activity Cellular Localization Regulation Of Ion Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Transmembrane Transport Muscle System Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Contraction Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Second-messenger-mediated Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Ion Homeostasis Positive Regulation Of Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Organic Cyclic Compound Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Transport Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Transport Response To Alkaloid Regulation Of Muscle Contraction Regulation Of Sequestering Of Calcium Ion Regulation Of Heart Contraction Response To Organonitrogen Compound Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Muscle Structure Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Myotube Differentiation Response To Stimulus Glutamate Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance
Tagcloud ?		aftn autonomously carry channel defects encoding familial former functioning graves gs gsalpha herein hypokalemic japanese kcne3 latter nodule paralysis periodic potassium rarely resolved stimulatory thyrotoxic thyrotropin tpp tshr understood	19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt
Tagcloud (Difference) ?		aftn autonomously carry channel defects encoding familial former functioning graves gs gsalpha herein hypokalemic japanese kcne3 latter nodule paralysis periodic potassium rarely resolved stimulatory thyrotoxic thyrotropin tpp tshr understood	19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt
Tagcloud (Intersection) ?