CACNA1S

Name	calcium voltage-gated channel subunit alpha1 S
Structure
Novel Interactors	2 novel interactors: KDR SLC25A17
Interactors	9 interactors: CCDC106 CYSRT1 MEOX2 NHERF4 REL RIMS2 RYR1 SRI TNKS
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Sarcoplasmic Reticulum T-tubule I Band Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Small Molecule Binding Metal Ion Binding Molecular Function Activator Activity
	Biological Process	Skeletal System Development Extraocular Skeletal Muscle Development Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Striated Muscle Contraction Endoplasmic Reticulum Organization Skeletal Muscle Tissue Development Myoblast Fusion Neuromuscular Junction Development Monoatomic Ion Transmembrane Transport Skeletal Muscle Adaptation Positive Regulation Of Muscle Contraction Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Muscle Cell Development Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Calcium Ion Import Across Plasma Membrane
Pathways	NCAM1 interactions
Drugs	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Pinaverium Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases	Hypokalemic periodic paralysis (HypoPP)
GWAS	Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cardiac Troponin-T levels ( 31014085 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 ) Glomerular filtration rate (creatinine) ( 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Inflammatory bowel disease ( 28067908 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Permanent tooth development ( 21931568 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Tooth agenesis ( 29364747 ) Ulcerative colitis ( 28067908 20228799 ) Urinary albumin-to-creatinine ratio ( 31511532 )
Entrez ID	779
HPRD ID	00248
Ensembl ID	ENSG00000081248
Uniprot IDs	B1ALM3 Q13698
PDB IDs	2VAY 6B27
GO Terms Enriched among Interactors ?	Regulation Of CGMP-mediated Signaling Epithelium Development Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Cell Migration Involved In Sprouting Angiogenesis Sarcoplasmic Reticulum Membrane FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Guanylate Cyclase Inhibitor Activity