SLC22A5

Gene Name		solute carrier family 22 (organic cation/carnitine transporter), member 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Carnitine Transmembrane Transporter Activity Drug Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding Antibiotic Transporter Activity
	Biological Process	Sodium Ion Transport Drug Transmembrane Transport Quaternary Ammonium Group Transport Carnitine Transport Drug Transport Antibiotic Transport Quorum Sensing Involved In Interaction With Host Transmembrane Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Carnitine Transmembrane Transport
Pathways		Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport
Drugs		L-Carnitine
Diseases
GWAS		Asthma ( 20860503) Crohn's disease ( 21102463) Fibrinogen ( 20031577) Height ( 20881960) Inflammatory bowel disease ( 23128233)
Protein-protein Interactions		4 interactors: PDZD3 PDZK1 SLC9A3R1 SLC9A3R2
Entrez ID		6584
HPRD ID		04539
Ensembl ID		ENSG00000197375
Uniprot IDs		O76082
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of CGMP Biosynthetic Process Renal Phosphate Ion Absorption Negative Regulation Of Guanylate Cyclase Activity Monocarboxylic Acid Transport Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Sodium Ion Transmembrane Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Ion Transport Bile Acid Secretion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Ion Transmembrane Transport Oligopeptide Transport Carnitine Transport Organic Anion Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Quaternary Ammonium Group Transport Regulation Of CGMP Biosynthetic Process Negative Regulation Of Lyase Activity Regulation Of Ion Transport Regulation Of Excretion Monovalent Inorganic Cation Transport Anion Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Cyclic-nucleotide-mediated Signaling Bile Acid And Bile Salt Transport Regulation Of CGMP Metabolic Process Positive Regulation Of Protein Targeting To Membrane Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Nucleotide Metabolic Process
Tagcloud ?		abstracted alleles c113y cardiomyopathy carnitine compound confirm corresponding deficiency detect frequently genomic heterozygous homozygous missense mutated mutation mutations nonsense parents pcd polyphen predict r254x r289x sanger sequencing sift throughput