Wiki-Pi
About
Search
People
Updates
Search
SLC22A5
Description
solute carrier family 22 member 5
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Basal Plasma Membrane
Membrane
Apical Plasma Membrane
Brush Border Membrane
Extracellular Exosome
Molecular Function
Nucleotide Binding
Protein Binding
ATP Binding
Amino-acid Betaine Transmembrane Transporter Activity
Carnitine Transmembrane Transporter Activity
Symporter Activity
Quaternary Ammonium Group Transmembrane Transporter Activity
Transmembrane Transporter Activity
PDZ Domain Binding
Xenobiotic Transmembrane Transporter Activity
(R)-carnitine Transmembrane Transporter Activity
Biological Process
Monoatomic Ion Transport
Sodium Ion Transport
Response To Symbiotic Bacterium
Quaternary Ammonium Group Transport
Carnitine Transport
Response To Type II Interferon
Response To Tumor Necrosis Factor
Xenobiotic Transport
Transmembrane Transport
Positive Regulation Of Intestinal Epithelial Structure Maintenance
Sodium-dependent Organic Cation Transport
Transport Across Blood-brain Barrier
(R)-carnitine Transport
(R)-carnitine Transmembrane Transport
Carnitine Transmembrane Transport
Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways
Carnitine shuttle
SLC-mediated transport of organic cations
Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Drugs
Levocarnitine
Diseases
Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
Crohn's disease
GWAS
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
31619474
29273806
20860503
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Brain morphology (MOSTest) (
32665545
)
Carotid plaque maximum area (
32469969
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
21102463
28067908
)
Diastolic blood pressure (
30578418
)
Fibrinogen (
20031577
)
Height (
20881960
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
Inflammatory bowel disease (
23128233
28067908
)
Intracranial aneurysm (
33199917
)
Low density lipoprotein cholesterol levels (
29083408
32154731
)
Maximum stenosis (
32469969
)
Mean area of carotid plaque (
32469969
)
Mean degree of stenosis (
32469969
)
Mean platelet volume (
32888494
)
Monocyte count (
32888494
)
Mosquito bite size (
28199695
)
Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) (
24823311
)
Serum metabolite levels (
23093944
33031748
)
Subcortical volume (MOSTest) (
32665545
)
Sum of carotid plaque area (
32469969
)
Ulcerative colitis (
28067908
)
White blood cell count (
32888494
)
Interacting Genes
11 interacting genes:
KRT27
KRT34
KRTAP6-3
MTUS2
NBPF19
NHERF1
NHERF2
NHERF4
NOTCH2NLA
PDZK1
SH3RF1
Entrez ID
6584
HPRD ID
04539
Ensembl ID
ENSG00000197375
Uniprot IDs
O76082
PDB IDs
Enriched GO Terms of Interacting Partners
?
Protein-membrane Adaptor Activity
Type 2 Metabotropic Glutamate Receptor Binding
Type 3 Metabotropic Glutamate Receptor Binding
Protein Localization To Plasma Membrane
Protein Localization To Cell Periphery
Protein Localization To Membrane
Apical Plasma Membrane
Signaling Receptor Binding
Intermediate Filament
Microvillus Membrane
Localization Within Membrane
Structural Constituent Of Skin Epidermis
Brush Border Membrane
Brush Border
Phosphatase Binding
Renal Phosphate Ion Absorption
Guanylate Cyclase Inhibitor Activity
Intermediate Filament Organization
Morphogenesis Of An Epithelium
PDZ Domain Binding
Regulation Of Renal Phosphate Excretion
Dopamine Receptor Binding
Apical Part Of Cell
Intermediate Filament Cytoskeleton Organization
Keratin Filament
Intermediate Filament-based Process
Epithelial Cell Differentiation
Tissue Morphogenesis
Beta-catenin Binding
Scavenger Receptor Binding
Growth Factor Receptor Binding
Carnitine Transmembrane Transport
Carnitine Transport
Maintenance Of Epithelial Cell Apical/basal Polarity
Bile Acid Secretion
Microvillus Assembly
Channel Activator Activity
Gamma-aminobutyric Acid Transmembrane Transporter Activity
Beta-2 Adrenergic Receptor Binding
Chloride Channel Regulator Activity
Gamma-aminobutyric Acid Import
Negative Regulation Of CGMP-mediated Signaling
Microvillus Organization
Establishment Of Golgi Localization
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Structural Molecule Activity
Intracellular Phosphate Ion Homeostasis
Tagcloud
?