SLC22A5 and PDZK1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vitro)

		SLC22A5	PDZK1
Description		solute carrier family 22 member 5	PDZ domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Amino-acid Betaine Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding Xenobiotic Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Response To Symbiotic Bacterium Quaternary Ammonium Group Transport Carnitine Transport Response To Type II Interferon Response To Tumor Necrosis Factor Xenobiotic Transport Transmembrane Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Transport Across Blood-brain Barrier (R)-carnitine Transport (R)-carnitine Transmembrane Transport Carnitine Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Carnitine shuttle SLC-mediated transport of organic cations Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Drugs		Levocarnitine
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP) Crohn's disease
GWAS		Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 31619474 29273806 20860503) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Carotid plaque maximum area ( 32469969) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Diastolic blood pressure ( 30578418) Fibrinogen ( 20031577) Height ( 20881960) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Intracranial aneurysm ( 33199917) Low density lipoprotein cholesterol levels ( 29083408 32154731) Maximum stenosis ( 32469969) Mean area of carotid plaque ( 32469969) Mean degree of stenosis ( 32469969) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum metabolite levels ( 23093944 33031748) Subcortical volume (MOSTest) ( 32665545) Sum of carotid plaque area ( 32469969) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)	Contrast sensitivity ( 24152035) Gout ( 32238385 33832965) Serum uric acid levels ( 30993211) Urate levels ( 20884846 23263486 31578528 31985003) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)
Interacting Genes		11 interacting genes: KRT27 KRT34 KRTAP6-3 MTUS2 NBPF19 NHERF1 NHERF2 NHERF4 NOTCH2NLA PDZK1 SH3RF1	30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		6584	5174
HPRD ID		04539	04829
Ensembl ID		ENSG00000197375	ENSG00000174827
Uniprot IDs		O76082	B2R7S7 Q5T2W1
PDB IDs			2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?		Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Apical Plasma Membrane Signaling Receptor Binding Intermediate Filament Microvillus Membrane Localization Within Membrane Structural Constituent Of Skin Epidermis Brush Border Membrane Brush Border Phosphatase Binding Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Intermediate Filament Organization Morphogenesis Of An Epithelium PDZ Domain Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Apical Part Of Cell Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Epithelial Cell Differentiation Tissue Morphogenesis Beta-catenin Binding Scavenger Receptor Binding Growth Factor Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Negative Regulation Of CGMP-mediated Signaling Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Structural Molecule Activity Intracellular Phosphate Ion Homeostasis	Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH
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