SLCO3A1 and NHERF2

Number of citations of the paper that reports this interaction (PubMedID 15553237)
0

Data Source:
HPRD (two hybrid)

		SLCO3A1	NHERF2
Description		solute carrier organic anion transporter family member 3A1	NHERF family PDZ scaffold protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Organic Anion Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Monoatomic Ion Transport Prostaglandin Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Sodium-independent Organic Anion Transport Positive Regulation Of MAPK Cascade Transmembrane Transport Transport Across Blood-brain Barrier	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Diastolic blood pressure ( 30224653) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate reduction (30%) ( 30955190) Gastroesophageal reflux disease ( 27485664) Inattentive symptoms ( 18821565) Neuritic plaque ( 25188341) Obesity-related traits ( 23251661) Orofacial cleft x maternal periconceptional alcohol use interaction (1df) ( 33937227) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary sclerosing cholangitis ( 27992413) Refractive error ( 32231278) Response to iloperidone treatment (QT prolongation) ( 18521091) Smoking initiation ( 24665060)
Interacting Genes		7 interacting genes: AQP6 ARLN GOLM1 NHERF1 NHERF2 NHERF4 TRARG1	46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		28232	9351
HPRD ID		07502	05946
Ensembl ID		ENSG00000176463	ENSG00000065054
Uniprot IDs		Q9UIG8	H3BQS0 Q15599
PDB IDs			2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Water Transport Localization Within Membrane Fluid Transport Endomembrane System Phosphatase Binding Nitrate Transmembrane Transporter Activity Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Apical Plasma Membrane Signaling Receptor Binding Apical Part Of Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Beta-catenin Binding Renal System Process Carbon Dioxide Transmembrane Transporter Activity Cytoplasmic Vesicle Membrane Carbon Dioxide Transmembrane Transport Cellular Localization Molecular Adaptor Activity Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Glucose Import In Response To Insulin Stimulus Monoatomic Anion Channel Activity Renal Water Transport Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Ammonium Channel Activity Intracellular Phosphate Ion Homeostasis Extracellular Matrix Structural Constituent Conferring Compression Resistance Perineuronal Net Ammonium Transmembrane Transport Water Channel Activity	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis
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