SLCO3A1 and PDZD3

Number of citations of the paper that reports this interaction (PMID 15553237)
5

Data Source:
HPRD (two hybrid)

		SLCO3A1	PDZD3
Gene Name		solute carrier organic anion transporter family, member 3A1	PDZ domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytosol Brush Border Subapical Complex Apical Part Of Cell
	Molecular Function	Transporter Activity	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity
	Biological Process	Sodium-independent Organic Anion Transport Transmembrane Transport	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance CGMP-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) DNA methylation (variation) ( 23725790) Inattentive symptoms ( 18821565) Obesity-related traits ( 23251661) Response to iloperidone treatment (QT prolongation) ( 18521091)
Protein-Protein Interactions		3 interactors: PDZD3 SLC9A3R1 SLC9A3R2	17 interactors: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		28232	79849
HPRD ID		07502	06191
Ensembl ID		ENSG00000176463	ENSG00000172367
Uniprot IDs		Q9UIG8	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of CGMP Biosynthetic Process Renal Phosphate Ion Absorption Negative Regulation Of Guanylate Cyclase Activity Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Intracellular Signal Transduction Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of CGMP Biosynthetic Process Negative Regulation Of Lyase Activity Regulation Of Excretion Regulation Of Sodium Ion Transmembrane Transporter Activity Cyclic-nucleotide-mediated Signaling Bile Acid And Bile Salt Transport Regulation Of CGMP Metabolic Process Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Water Transport Protein Complex Assembly Anion Homeostasis Fluid Transport Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Transmembrane Transport Ion Transport Ion Transmembrane Transport Sodium-independent Organic Anion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Drug Transport Monocarboxylic Acid Transport Quaternary Ammonium Group Transport Transport Cation Transmembrane Transport Drug Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Antibiotic Transport Toxin Transport Ammonium Transmembrane Transport Organic Cation Transport Cation Transport Oligopeptide Transport Ammonium Transport Response To Drug Inorganic Anion Transport Carnitine Transmembrane Transport Carnitine Transport Lipid Transport Lipid Localization Monovalent Inorganic Cation Transport Dipeptide Transport Histamine Uptake Positive Regulation Of ARF GTPase Activity Short-chain Fatty Acid Import Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Intestinal Epithelial Structure Maintenance Quorum Sensing Involved In Interaction With Host Sodium-dependent Organic Cation Transport Fatty Acid Transport Regulation Of Intestinal Epithelial Structure Maintenance Prostaglandin Transport Peptide Transport Hormone Transport Extraocular Skeletal Muscle Development Oligopeptide Transmembrane Transport Regulation Of Chloride Transport Amide Transport Iodide Transport Thyroid Hormone Transport Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis
Tagcloud ?		2b1 abcb1 abcc1 abcc2 abcc3 abcc4 abcc5 abcg2 antiretroviral antiretrovirals bcrp darunavir fold gp ls180 mdr1 mrp1 mrp2 mrp3 mrp4 mrp5 pharmacokinetics sanctuary saquinavir suboptimal transporters transporting
Tagcloud (Difference) ?		2b1 abcb1 abcc1 abcc2 abcc3 abcc4 abcc5 abcg2 antiretroviral antiretrovirals bcrp darunavir fold gp ls180 mdr1 mrp1 mrp2 mrp3 mrp4 mrp5 pharmacokinetics sanctuary saquinavir suboptimal transporters transporting
Tagcloud (Intersection) ?