ABCC2 and HSPA4

Number of citations of the paper that reports this interaction (PubMedID 21059598)
0

Data Source:
BioGRID (pull down)

		ABCC2	HSPA4
Description		ATP binding cassette subfamily C member 2	heat shock protein family A (Hsp70) member 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Intercellular Canaliculus	Nucleus Cytoplasm Cytosol Organelle Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Negative Regulation Of Gene Expression Bile Acid And Bile Salt Transport Bilirubin Transport Heme Catabolic Process Xenobiotic Export From Cell Carboxylic Acid Transport Transmembrane Transport Transepithelial Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier Xenobiotic Transport Across Blood-brain Barrier	Protein Folding Response To Unfolded Protein Protein Import Into Mitochondrial Matrix Chaperone-mediated Protein Complex Assembly
Pathways		Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS Aspirin ADME Paracetamol ADME Atorvastatin ADME	Regulation of HSF1-mediated heat shock response
Drugs		ATP Sulfinpyrazone Azvudine	Phenethyl Isothiocyanate
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 24737748 26151821) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum metabolite levels ( 33031748) Stent thrombosis in response to clopidogrel treatment ( 32472697)	A body shape index ( 34021172) Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 31928498 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 NHERF1 NHERF4 PDZK1 RDX SHANK3 TUBB3 UBQLN1	72 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BRMS1 CALM1 CD40 CDC73 CDKN2A CEBPA CSNK1A1 CSNK2A1 DDIT4 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSF2 HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STIP1 STK4 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A
Entrez ID		1244	3308
HPRD ID		03065	09025
Ensembl ID		ENSG00000023839	ENSG00000170606
Uniprot IDs		Q92887	P34932
PDB IDs		8IZQ 8IZR 8JX7 8JXQ 8JXU 8JY4 8JY5 9BR2 9BUK 9C12 9C2I
Enriched GO Terms of Interacting Partners?		Protein-membrane Adaptor Activity Protein Localization To Membrane Intracellular Protein Localization Protein Localization To Plasma Membrane Microvillus Assembly Protein Localization To Cell Periphery Microvillus Organization Localization Within Membrane Filopodium Apical Part Of Cell Cell Periphery Apical Plasma Membrane Microvillus Membrane Regulation Of Transport Stereocilium Brush Border Membrane Regulation Of Cellular Component Size Renal Phosphate Ion Absorption Negative Regulation Of Store-operated Calcium Channel Activity Guanylate Cyclase Inhibitor Activity Brush Border Extracellular Exosome NF-kappaB P50/p65 Complex PDZ Domain Binding Microvillus Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Cell Size Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Netrin Receptor Binding Ornithine Decarboxylase Activator Activity Positive Regulation Of Polyamine Transmembrane Transport Guanylate Kinase-associated Protein Clustering ERAD Pathway Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex Regulation Of Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Type 3 Metabotropic Glutamate Receptor Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Ornithine Decarboxylase Activity Putrescine Biosynthetic Process From Arginine, Via Ornithine Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Vitamin D Biosynthetic Process Signaling Receptor Binding Cellular Localization Regulation Of Monoatomic Ion Transport Scavenger Receptor Binding Stereocilium Base	Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cytosol Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Response To Lipid Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Protein Stability Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?