ABCC2 and AZIN1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ABCC2	AZIN1
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 2	antizyme inhibitor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Intercellular Canaliculus	Nucleus Cytosol
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances	Catalytic Activity Enzyme Inhibitor Activity Ornithine Decarboxylase Activator Activity
	Biological Process	Transport Drug Transmembrane Transport Response To Oxidative Stress Metabolic Process Response To Heat Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport	Regulation Of Cellular Amino Acid Metabolic Process Polyamine Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Small Molecule Metabolic Process Positive Regulation Of Polyamine Transmembrane Transport
Pathways		ABC-family proteins mediated transport	Regulation of ornithine decarboxylase (ODC) Metabolism of amino acids and derivatives
Drugs		Adenosine triphosphate Sulfinpyrazone
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AZIN1 CANX MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 UBQLN1	6 interactors: ABCC2 ADSSL1 FANCA FANCC KHDRBS1 OAZ3
Entrez ID		1244	51582
HPRD ID		03065	07443
Ensembl ID		ENSG00000023839	ENSG00000155096
Uniprot IDs		Q92887	O14977
PDB IDs
Enriched GO Terms of Interacting Partners?		Microvillus Assembly Microvillus Organization Protein Localization Renal Phosphate Ion Absorption Negative Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of CGMP Biosynthetic Process Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Polyamine Transmembrane Transport Postsynaptic Density Assembly Guanylate Kinase-associated Protein Clustering Glutathione Transport Regulation Of Cytoskeleton Organization Negative Regulation Of Calcidiol 1-monooxygenase Activity Regulation Of Long Term Synaptic Depression Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Volume Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Chromosome Condensation Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Catalytic Activity Cellular Protein Localization Regulation Of Transmembrane Transporter Activity Cellular Localization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Ion Transport Negative Regulation Of Vitamin D Biosynthetic Process Renal Sodium Ion Transport N-methyl-D-aspartate Receptor Clustering Vocal Learning Positive Regulation Of Synapse Structural Plasticity Negative Regulation Of Cytoskeleton Organization Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Transport Positive Regulation Of Ion Transport Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Positive Regulation Of Long-term Neuronal Synaptic Plasticity Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Nicotine Negative Regulation Of Catalytic Activity	Putrescine Transport Prostaglandin Transport Positive Regulation Of RNA Export From Nucleus 'de Novo' AMP Biosynthetic Process Negative Regulation Of Polyamine Transmembrane Transport AMP Biosynthetic Process Reproduction Aspartate Metabolic Process Thyroid Hormone Transport Cellular Chloride Ion Homeostasis Cellular Nitrogen Compound Metabolic Process Single Organism Reproductive Process Response To Methotrexate Chloride Ion Homeostasis Cellular Response To Electrical Stimulus Reproductive Process Regulation Of RNA Export From Nucleus Response To Muscle Activity Nitrogen Compound Metabolic Process Positive Regulation Of Translational Initiation AMP Metabolic Process Anion Transmembrane Transport Polyamine Biosynthetic Process Response To Oxidative Stress Removal Of Superoxide Radicals Response To Stress Cellular Response To Superoxide IMP Metabolic Process Amine Biosynthetic Process Response To Drug Response To Superoxide Response To Arsenic-containing Substance Response To Oxygen Radical Polyamine Metabolic Process Drug Transmembrane Transport
Tagcloud ?		24c 24t 388g 521c abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www	adar1 adenosine antizyme augmented beta15 ccnd1 collectively conferred conformational deaminase decarboxylase driver edited editing encoding glycine hcc hepatocellular initiating inosine manifested neutralization odc ornithine resultant strand stronger substitution transcriptome
Tagcloud (Difference) ?		24c 24t 388g 521c abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www	adar1 adenosine antizyme augmented beta15 ccnd1 collectively conferred conformational deaminase decarboxylase driver edited editing encoding glycine hcc hepatocellular initiating inosine manifested neutralization odc ornithine resultant strand stronger substitution transcriptome
Tagcloud (Intersection) ?