S100A1 and CNTF

Number of citations of the paper that reports this interaction (PubMedID 34933172)
0

Data Source:
BioGRID (pull down)

		S100A1	CNTF
Description		S100 calcium binding protein A1	ciliary neurotrophic factor
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Sarcoplasmic Reticulum Z Disc M Band A Band I Band Protein-containing Complex	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Glial Cell Projection
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding ATPase Binding	Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Vasodilation Positive Regulation Of Sprouting Angiogenesis	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Astrocyte Activation Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand	IL-6-type cytokine receptor ligand interactions
Drugs		Olopatadine
Diseases
GWAS			Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 23128233) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)
Interacting Genes		36 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 CLCF1 CNTF CTF1 DES FKBP4 GFAP GJA1 IFNB1 IL11 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1 TP53	16 interacting genes: AK8 APOE CNTFR CYSRT1 IL6R IL6ST KRT31 KRT40 LIFR NDUFAB1 RDM1 S100A1 S100A6 S100P TEPSIN TRIP6
Entrez ID		6271	1270
HPRD ID		01489	00347
Ensembl ID		ENSG00000160678	ENSG00000242689
Uniprot IDs		A0A0S2Z4H2 P23297	P26441
PDB IDs		2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89	1CNT 8D74
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding S100 Protein Binding Transition Metal Ion Binding Identical Protein Binding Calcium Ion Binding Calcium Ion-transporting ATPase Complex Negative Regulation Of Blood Circulation Regulation Of Blood Circulation Regulation Of System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Actinomycin D Cell Surface Receptor Signaling Pathway Via STAT Cell Body Response To Actinomycin D Cellular Response To UV-C Ciliary Neurotrophic Factor Receptor Binding Sarcoplasmic Reticulum Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cardiac Muscle Cell Membrane Potential Cytokine Activity Intercalated Disc Muscle System Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Antibiotic Negative Regulation Of ATP-dependent Activity RAGE Receptor Binding Developmental Process Relaxation Of Cardiac Muscle Response To Hypoxia Cell Activation Response To UV-C Sarcoplasmic Reticulum Response To Decreased Oxygen Levels Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Sarcoplasmic Reticulum Calcium Ion Transport Modulation Of Chemical Synaptic Transmission Regulation Of Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Response To Oxygen Levels Astrocyte Activation Astrocyte Development Intracellular Calcium Ion Homeostasis Regulation Of Programmed Cell Death Regulation Of Heart Contraction Relaxation Of Muscle Cellular Response To UV Negative Regulation Of Heart Contraction Circadian Behavior Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Rhythmic Behavior	Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Interleukin-11-mediated Signaling Pathway Cytokine Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Interleukin-6 Receptor Complex Oncostatin-M Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Ciliary Neurotrophic Factor Receptor Binding Regulation Of Platelet Activation Interleukin-6 Receptor Binding Structural Molecule Activity Protein Homodimerization Activity Positive Regulation Of Platelet Aggregation Calcium-dependent Protein Binding T-helper 17 Cell Lineage Commitment S100 Protein Binding Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment External Side Of Plasma Membrane Regulation Of Platelet Aggregation T Cell Lineage Commitment Cytokine-mediated Signaling Pathway Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Receptor Complex Ciliary Neurotrophic Factor Binding Growth Factor Binding Acyl Carrier Activity Coated Vesicle Membrane Vasodilation Structural Constituent Of Skin Epidermis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Presynaptic Membrane Organization
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