S100A1 and S100A4

Number of citations of the paper that reports this interaction (PMID 10753920)
13

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		S100A1	S100A4
Gene Name		S100 calcium binding protein A1	S100 calcium binding protein A4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Sarcoplasmic Reticulum Z Disc M Band Neuron Projection Protein Complex	Extracellular Space Nucleus Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding	Actin Binding Calcium Ion Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Voltage-gated Calcium Channel Activity	Epithelial To Mesenchymal Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways
Drugs		Olopatadine
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ACTA1 AGER ANXA6 ATP2A2 CACYBP CAPZA1 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM RYR1 S100A2 S100A4 S100B S100P SYN1	22 interactors: ACTA1 ANXA2 BAG6 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 NOV PPFIBP1 S100A1 S100B S100P SEPT2 SEPT6 SEPT7 SMAD3 TP53 TPM2 TPM3 UNC119
Entrez ID		6271	6275
HPRD ID		01489	15914
Ensembl ID		ENSG00000160678	ENSG00000196154
Uniprot IDs		P23297	P26447
PDB IDs		2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX	1M31 2LNK 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4ETO 4HSZ
Enriched GO Terms of Interacting Partners?		Muscle System Process Response To Abiotic Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Protein Complex Assembly Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Muscle Contraction Relaxation Of Cardiac Muscle Regulation Of Striated Muscle Contraction Glycogen Catabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Polysaccharide Catabolic Process Calcium Ion Transport Relaxation Of Muscle Striated Muscle Tissue Development Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Response To Hormone Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Metal Ion Muscle Tissue Development Cellular Component Assembly Myotube Cell Development Regulation Of Cellular Localization Cellular Carbohydrate Catabolic Process Regulation Of The Force Of Heart Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Response To Wounding Regulation Of Ion Homeostasis Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Cellular Response To Alkaloid Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Astrocyte Differentiation Cytosolic Calcium Ion Homeostasis Cellular Cation Homeostasis Actin-mediated Cell Contraction Cellular Ion Homeostasis Response To Peptide Hormone Cardiac Conduction Tissue Development Negative Regulation Of Striated Muscle Tissue Development Steroid Hormone Receptor Complex Assembly Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Schwann Cell Proliferation	Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Cell Cycle Process Cytokinesis Cell Cycle Actin Filament-based Process Muscle Contraction Cell Division Movement Of Cell Or Subcellular Component Muscle System Process Regulation Of Cell Shape Plasma Membrane Repair Response To External Stimulus Anatomical Structure Morphogenesis Cellular Component Assembly Anatomical Structure Formation Involved In Morphogenesis Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Response To Abiotic Stimulus Mitotic Cell Cycle Regulation Of Cell Morphogenesis Cellular Response To Light Stimulus Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cell Development Response To Hypoxia Cellular Response To Oxygen Levels Actomyosin Structure Organization Signal Transduction By P53 Class Mediator Wound Healing Response To Light Stimulus Response To Stimulus Regulation Of Protein Stability Cellular Response To Radiation Cell Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Wounding Cell Differentiation Anatomical Structure Development Immune System Process Cellular Response To Stimulus System Development Cell Projection Organization Positive Regulation Of Transport Cell Adhesion
Tagcloud ?		ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses	aldh1 anatomically area areas biomarkers cadherin cd44 central detailed egfr expressions fgfr1 heterogeneous immunohistochemical lymph metastatic molecules node nodes peripheral precise prediction recurrence relationships shorter sox2 squamous staining vegfr2
Tagcloud (Difference) ?		ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses	aldh1 anatomically area areas biomarkers cadherin cd44 central detailed egfr expressions fgfr1 heterogeneous immunohistochemical lymph metastatic molecules node nodes peripheral precise prediction recurrence relationships shorter sox2 squamous staining vegfr2
Tagcloud (Intersection) ?