S100A1 and S100A2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		S100A1	S100A2
Description		S100 calcium binding protein A1	S100 calcium binding protein A2
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Sarcoplasmic Reticulum Z Disc M Band A Band I Band Protein-containing Complex
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding ATPase Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Vasodilation Positive Regulation Of Sprouting Angiogenesis	Endothelial Cell Migration
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs		Olopatadine	Olopatadine Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS
Interacting Genes		36 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 CLCF1 CNTF CTF1 DES FKBP4 GFAP GJA1 IFNB1 IL11 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1 TP53	16 interacting genes: ARL13B CEP20 EPO FAM209A FKBP4 MDM2 PPID S100A1 S100A3 S100B S100P STUB1 TP53 TPM1 TPM2 TPM3
Entrez ID		6271	6273
HPRD ID		01489	01508
Ensembl ID		ENSG00000160678	ENSG00000196754
Uniprot IDs		A0A0S2Z4H2 P23297	P29034 Q5RHS7 R4GN49
PDB IDs		2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89	2RGI 4DUQ
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding S100 Protein Binding Transition Metal Ion Binding Identical Protein Binding Calcium Ion Binding Calcium Ion-transporting ATPase Complex Negative Regulation Of Blood Circulation Regulation Of Blood Circulation Regulation Of System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Actinomycin D Cell Surface Receptor Signaling Pathway Via STAT Cell Body Response To Actinomycin D Cellular Response To UV-C Ciliary Neurotrophic Factor Receptor Binding Sarcoplasmic Reticulum Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cardiac Muscle Cell Membrane Potential Cytokine Activity Intercalated Disc Muscle System Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Antibiotic Negative Regulation Of ATP-dependent Activity RAGE Receptor Binding Developmental Process Relaxation Of Cardiac Muscle Response To Hypoxia Cell Activation Response To UV-C Sarcoplasmic Reticulum Response To Decreased Oxygen Levels Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Sarcoplasmic Reticulum Calcium Ion Transport Modulation Of Chemical Synaptic Transmission Regulation Of Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Response To Oxygen Levels Astrocyte Activation Astrocyte Development Intracellular Calcium Ion Homeostasis Regulation Of Programmed Cell Death Regulation Of Heart Contraction Relaxation Of Muscle Cellular Response To UV Negative Regulation Of Heart Contraction Circadian Behavior Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Rhythmic Behavior	Muscle Thin Filament Tropomyosin Calcium-dependent Protein Binding Cellular Response To Actinomycin D Response To Hypoxia Response To Decreased Oxygen Levels Tau Protein Binding Response To Actinomycin D Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Cellular Response To UV-C Response To Oxygen Levels Cellular Response To Oxygen Levels Heat Shock Protein Binding Protein Homodimerization Activity Cellular Response To Antibiotic Regulation Of Blood Circulation Cellular Response To UV Response To UV-C Identical Protein Binding S100 Protein Binding Actin Filament Regulation Of System Process Response To Salt Stress Cellular Response To Light Stimulus Transition Metal Ion Binding Cytoplasm System Process Cytoskeleton Disordered Domain Specific Binding Cellular Response To Gamma Radiation Response To UV Cytosol Regulation Of ATP-dependent Activity Peptidyl-prolyl Cis-trans Isomerase Activity Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Embryo Implantation Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Erythrocyte Apoptotic Process Steroid Hormone Receptor Complex Assembly Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Heart Contraction DNA Damage Response, Signal Transduction By P53 Class Mediator Supramolecular Fiber Organization Hsp90 Protein Binding Hsp70 Protein Binding Regulation Of Mitophagy
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