Wiki-Pi
About
Search
People
Updates
Search
FAF1 and CD40
Number of citations of the paper that reports this interaction (PubMedID
24810049
)
31
Data Source:
BioGRID
(affinity chromatography technology, pull down, two hybrid)
FAF1
CD40
Description
Fas associated factor 1
CD40 molecule
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Endomembrane System
CD95 Death-inducing Signaling Complex
VCP-NPL4-UFD1 AAA ATPase Complex
Perinuclear Region Of Cytoplasm
Ooplasm
Extracellular Region
Extracellular Space
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
CD40 Receptor Complex
Neuronal Cell Body
Varicosity
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Protein Domain Specific Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
NF-kappaB Binding
Antigen Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Biological Process
Apoptotic Process
Regulation Of Cell Adhesion
Fas Signaling Pathway
ERAD Pathway
Regulation Of Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of DNA Replication
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Immune System Process
Regulation Of Immunoglobulin Production
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Calcium Ion Homeostasis
Defense Response
Inflammatory Response
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Bacterium
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
B Cell Mediated Immunity
CD40 Signaling Pathway
Platelet Activation
Positive Regulation Of B Cell Proliferation
Response To Nutrient Levels
Positive Regulation Of Interleukin-12 Production
Response To Cobalamin
Response To Type II Interferon
Cellular Response To Erythropoietin
B Cell Proliferation
B Cell Activation
Defense Response To Protozoan
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Immune Response
Positive Regulation Of Developmental Process
Positive Regulation Of Multicellular Organismal Process
Defense Response To Virus
Protein-containing Complex Assembly
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Protein Kinase C Signaling
Response To Peptide
Positive Regulation Of Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Drugs
Lucatumumab
Dacetuzumab
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS
Appendicular lean mass (
33097823
)
Atrial fibrillation (
29290336
)
Blood urea nitrogen levels (
31152163
)
Body mass index and type 2 diabetes (pairwise) (
33619380
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Depression and alcohol dependence (
22064162
)
FEV1 (
30804560
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
25673412
34021172
)
Hippocampal tail volume (corrected for total hippocampal volume) (
30279459
)
Ischemic stroke (large artery atherosclerosis) (
26732560
)
Left ventricle wall thickness (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Lung function (FEV1/FVC) (
30804560
)
Lymphocyte percentage of white cells (
32888494
)
Male-pattern baldness (
28196072
)
Mean reticulocyte volume (
32888494
)
Multisite chronic pain (
33830993
31194737
)
Neutrophil percentage of white cells (
32888494
)
Pancreas fat (
34128465
)
Peak expiratory flow (
30804560
)
Postprandial triglyceride response (
32603185
)
Pulse pressure (
30578418
27841878
)
QRS duration (
21076409
30679814
)
Renal cell carcinoma (
28598434
)
Reticulocyte fraction of red cells (
32888494
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
30297969
24509480
26818947
28869590
30718926
32499647
)
Ventricular ectopy (
29618737
)
Ventricular ectopy or supraventricular ectopy (pleiotropy) (
29618737
)
Blood protein levels in cardiovascular risk (
28369058
)
Chronic hepatitis B infection (
25802187
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
23128233
28067908
)
Kawasaki disease (
33106546
22446961
22446962
)
Multiple sclerosis (
19525955
24076602
22190364
21833088
)
Rheumatoid arthritis (
24390342
23143596
30423114
18794853
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Systemic lupus erythematosus (
28714469
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
49 interacting genes:
AKT1
ANXA1
ANXA7
ASCC2
CASP8
CBS
CD40
CDC73
CDKN1A
CREBBP
CSNK2A1
CSNK2B
DNAJB11
FADD
FAF2
FAS
HSD17B10
HSPA1B
IGF2
IKBKB
ITGB1BP1
NEDD8
NGLY1
NLRP12
NLRP2
NLRP3
NLRP7
NR1H2
NR4A1
PRKN
RAP1A
RAP1B
RCC1
RELA
SIRT6
SKIL
SNIP1
SPOP
SUMO1
TAF1D
TK1
TNNT1
TSC22D1
UBC
UBE2I
UROD
WWP2
XIAP
YTHDF3
44 interacting genes:
BIRC2
BIRC3
CAV1
CBL
CD40LG
CMTM5
CMTM6
CYB561A3
DEFB121
EBP
FAF1
HSPA4
HSPA8
IL4R
INSIG2
JAK3
MAL
MAP3K8
MIP
MS4A1
NCOA6
NSMAF
PIK3R1
PLP1
RIPK2
SLC30A2
SLC30A3
SLC39A13
SLC61A1
SLC7A1
TANK
TDP2
TLCD1
TMEM107
TMEM128
TMEM147
TRAF1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRAF6
XRCC5
XRCC6
Entrez ID
11124
958
HPRD ID
05124
00178
Ensembl ID
ENSG00000185104
ENSG00000101017
Uniprot IDs
Q9UNN5
A0A0S2Z349
A0A0S2Z3C7
A0A8Q3SI60
P25942
Q6P2H9
PDB IDs
1H8C
2DZM
2EC4
3E21
3QC8
3QCA
3QQ8
3QWZ
3QX1
3R3M
7FGM
7FGN
8KG2
1CZZ
1D00
1FLL
1LB6
3QD6
5DMI
5DMJ
5IHL
6FAX
6PE8
6PE9
7P3I
8YX1
8YX9
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Proteolysis
Ubiquitin Protein Ligase Binding
Negative Regulation Of Biosynthetic Process
Cytosol
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Defense Response
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Lipid
Cytoplasm
Positive Regulation Of Protein Metabolic Process
Regulation Of Interleukin-1 Production
Regulation Of Innate Immune Response
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Identical Protein Binding
Regulation Of Immune System Process
Negative Regulation Of Signal Transduction
Nucleus
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
CD95 Death-inducing Signaling Complex
Positive Regulation Of Defense Response
Catabolic Process
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
CD40 Signaling Pathway
CD40 Receptor Complex
Tumor Necrosis Factor Receptor Binding
Thioesterase Binding
Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Signaling Adaptor Activity
Cell Surface Receptor Signaling Pathway
Response To Stress
Regulation Of Immune Response
Regulation Of Innate Immune Response
Cytoplasmic Side Of Plasma Membrane
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Immune System Process
Positive Regulation Of Protein Modification Process
Response To Other Organism
Positive Regulation Of Post-translational Protein Modification
Non-canonical NF-kappaB Signal Transduction
Ubiquitin Protein Ligase Binding
Regulation Of Defense Response
Defense Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of Immune System Process
Immune Response
Positive Regulation Of Lymphocyte Activation
Regulation Of Apoptotic Process
Toll-like Receptor 4 Signaling Pathway
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ubiquitin Protein Ligase Activity
Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein-containing Complex
Protein Binding
CD40 Receptor Binding
Defense Response To Other Organism
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Immune System Process
Regulation Of Programmed Cell Death
Response To External Biotic Stimulus
Innate Immune Response
Positive Regulation Of Protein Ubiquitination
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of DNA-binding Transcription Factor Activity
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?