FAF1 and NLRP2

Number of citations of the paper that reports this interaction (PMID 17046979)
7

Data Source:
BioGRID (two hybrid)

		FAF1	NLRP2
Gene Name		Fas (TNFRSF6) associated factor 1	NLR family, pyrin domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Cytosol CD95 Death-inducing Signaling Complex Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding	Protein Binding ATP Binding Pyrin Domain Binding
	Biological Process	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion
Pathways
Drugs
Diseases
GWAS		Depression and alcohol dependence ( 22064162) Ventricular conduction ( 21076409)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		37 interactors: ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 TAF1D TK1 TNNT1 TSC22D1 UROD VAPB	4 interactors: APP CARD8 FAF1 PYDC2
Entrez ID		11124	55655
HPRD ID		05124	14805
Ensembl ID		ENSG00000185104	ENSG00000022556
Uniprot IDs		B4DEJ6 Q9UNN5	J3KN39 Q9NX02
PDB IDs		1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Cyclic Compound Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Response To Lipid Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Steroid Hormone Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Establishment Of Protein Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Endopeptidase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Peptidase Activity Response To External Stimulus Regulation Of Protein Localization Regulation Of Cellular Localization Leukocyte Homeostasis Regulation Of Immune System Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Kinase Activity Cell Communication Intracellular Receptor Signaling Pathway	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Collateral Sprouting In Absence Of Injury Positive Regulation Of Proteolysis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Endopeptidase Activity Axon Choice Point Recognition Cytoplasmic Sequestering Of NF-kappaB Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Neuron Remodeling Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport Negative Regulation Of NF-kappaB Import Into Nucleus Cellular Copper Ion Homeostasis Regulation Of Signaling Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Interleukin-1 Secretion Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Kinase Activity Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Sequestering Of Protein Regulation Of Kinase Activity Regulation Of Protein Localization Positive Regulation Of Interleukin-1 Beta Production Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Mating Behavior
Tagcloud ?		agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual	1alpha 1beta adenosine aim2 analogs atp atpgammas benzoylbenzoyl bzatp danger fibrosis immunochemistry inflammasome lipopolysaccharide macrophages monocyte natively nlrc4 nlrp1 nlrp3 nlrp6 p2x7 potentiate primed purinergic salt tetralithium thio triphosphate
Tagcloud (Difference) ?		agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual	1alpha 1beta adenosine aim2 analogs atp atpgammas benzoylbenzoyl bzatp danger fibrosis immunochemistry inflammasome lipopolysaccharide macrophages monocyte natively nlrc4 nlrp1 nlrp3 nlrp6 p2x7 potentiate primed purinergic salt tetralithium thio triphosphate
Tagcloud (Intersection) ?