FAF1 and SPOP

Number of citations of the paper that reports this interaction (PubMedID 28805822)
55

Data Source:
BioGRID (two hybrid)

		FAF1	SPOP
Description		Fas associated factor 1	speckle type BTB/POZ protein
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Endomembrane System CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Perinuclear Region Of Cytoplasm Ooplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Molecular Function Inhibitor Activity
	Biological Process	Apoptotic Process Regulation Of Cell Adhesion Fas Signaling Pathway ERAD Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Hedgehog 'on' state SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29290336) Blood urea nitrogen levels ( 31152163) Body mass index and type 2 diabetes (pairwise) ( 33619380) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression and alcohol dependence ( 22064162) FEV1 ( 30804560) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Left ventricle wall thickness ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 33830993 31194737) Neutrophil percentage of white cells ( 32888494) Pancreas fat ( 34128465) Peak expiratory flow ( 30804560) Postprandial triglyceride response ( 32603185) Pulse pressure ( 30578418 27841878) QRS duration ( 21076409 30679814) Renal cell carcinoma ( 28598434) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 24509480 26818947 28869590 30718926 32499647) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)	Prostate cancer ( 23535732)
Interacting Genes		49 interacting genes: AKT1 ANXA1 ANXA7 ASCC2 CASP8 CBS CD40 CDC73 CDKN1A CREBBP CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 HSPA1B IGF2 IKBKB ITGB1BP1 NEDD8 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 PRKN RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 SPOP SUMO1 TAF1D TK1 TNNT1 TSC22D1 UBC UBE2I UROD WWP2 XIAP YTHDF3	74 interacting genes: AEN AMOTL2 AR ATM BRAF BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 DAXX DDIT3 DHX15 DPPA2 DUSP7 EGLN2 ERF ERG FAF1 G3BP1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HIPK2 HMGCS1 ILF3 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NUDCD3 PDPK1 PDX1 PIAS1 PIAS3 PTEN RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TP53BP1 TPD52 TRAF1 TRAF6 TWIST1 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8
Entrez ID		11124	8405
HPRD ID		05124	16004
Ensembl ID		ENSG00000185104	ENSG00000121067
Uniprot IDs		Q9UNN5	O43791
PDB IDs		1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M 7FGM 7FGN 8KG2	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D 7KLZ 7LIN 7LIO 7LIP 7LIQ 8DWS 8DWT 8DWU 8DWV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Cytosol Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Cytoplasm Positive Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Production Regulation Of Innate Immune Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Immune System Process Negative Regulation Of Signal Transduction Nucleus Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Interleukin-1 Beta Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Positive Regulation Of Defense Response Catabolic Process	Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Positive Regulation Of Biosynthetic Process SUMO Transferase Activity Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck DNA-binding Transcription Factor Activity Regulation Of Signal Transduction Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Stress Chromatin Organization Post-translational Protein Modification Regulation Of Programmed Cell Death Chromatin Remodeling Sequence-specific DNA Binding DNA Binding
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