FAF1 and TSC22D1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		FAF1	TSC22D1
Gene Name		Fas (TNFRSF6) associated factor 1	TSC22 domain family, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Cytosol CD95 Death-inducing Signaling Complex Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Depression and alcohol dependence ( 22064162) Ventricular conduction ( 21076409)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956)
Protein-Protein Interactions		37 interactors: ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 TAF1D TK1 TNNT1 TSC22D1 UROD VAPB	49 interactors: A2M APLP1 ASAH1 C14orf1 C9orf9 CACNA1A CARHSP1 CCDC90B CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED FAF1 FAM20C FBN3 GNB2 GNB5 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 OTUB1 PDHB PRKCI PTN QARS RGS1 RPL5 SETDB1 SP110 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WDYHV1 WIZ WNK1 ZC3HC1
Entrez ID		11124	8848
HPRD ID		05124	07414
Ensembl ID		ENSG00000185104
Uniprot IDs		B4DEJ6 Q9UNN5	A8K3Y6 Q15714
PDB IDs		1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Cyclic Compound Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Response To Lipid Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Steroid Hormone Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Establishment Of Protein Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Endopeptidase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Peptidase Activity Response To External Stimulus Regulation Of Protein Localization Regulation Of Cellular Localization Leukocyte Homeostasis Regulation Of Immune System Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Kinase Activity Cell Communication Intracellular Receptor Signaling Pathway	Regulation Of Metabolic Process Chromatin Organization Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Chromosome Organization Regulation Of Chromosome Organization Regulation Of Histone Modification Regulation Of Protein Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Methylation Histone Modification Gene Expression Cellular Nitrogen Compound Metabolic Process Peptidyl-threonine Phosphorylation RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Heterocycle Metabolic Process Regulation Of Histone Methylation Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Signal Transduction Transcription, DNA-templated Cellular Response To Stimulus Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Response To Stimulus Protein Methylation Positive Regulation Of Histone Modification Regulation Of Transcription, DNA-templated Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Signaling Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cell Communication Histone Lysine Methylation Negative Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual	beadchip capn13 cards cic collect conjunctival cxcl6 cytology drb5 dry entire eye ht illumina impression investigates lysozyme mini optimally optimization psca qiagen qrt qualifying rneasy severities steps taqman transcriptome
Tagcloud (Difference) ?		agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual	beadchip capn13 cards cic collect conjunctival cxcl6 cytology drb5 dry entire eye ht illumina impression investigates lysozyme mini optimally optimization psca qiagen qrt qualifying rneasy severities steps taqman transcriptome
Tagcloud (Intersection) ?