FAF1 and NGLY1

Number of citations of the paper that reports this interaction (PubMedID 28443643)
49

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FAF1	NGLY1
Description		Fas associated factor 1	N-glycanase 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Endomembrane System CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Perinuclear Region Of Cytoplasm Ooplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Apoptotic Process Regulation Of Cell Adhesion Fas Signaling Pathway ERAD Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein Folding Glycoprotein Catabolic Process Positive Regulation Of BMP Signaling Pathway
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29290336) Blood urea nitrogen levels ( 31152163) Body mass index and type 2 diabetes (pairwise) ( 33619380) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression and alcohol dependence ( 22064162) FEV1 ( 30804560) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Left ventricle wall thickness ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 33830993 31194737) Neutrophil percentage of white cells ( 32888494) Pancreas fat ( 34128465) Peak expiratory flow ( 30804560) Postprandial triglyceride response ( 32603185) Pulse pressure ( 30578418 27841878) QRS duration ( 21076409 30679814) Renal cell carcinoma ( 28598434) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 24509480 26818947 28869590 30718926 32499647) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		49 interacting genes: AKT1 ANXA1 ANXA7 ASCC2 CASP8 CBS CD40 CDC73 CDKN1A CREBBP CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 HSPA1B IGF2 IKBKB ITGB1BP1 NEDD8 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 PRKN RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 SPOP SUMO1 TAF1D TK1 TNNT1 TSC22D1 UBC UBE2I UROD WWP2 XIAP YTHDF3	19 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBC UBQLN1 UBXN2B VCP VMAC
Entrez ID		11124	55768
HPRD ID		05124	10118
Ensembl ID		ENSG00000185104	ENSG00000151092
Uniprot IDs		Q9UNN5	Q96IV0
PDB IDs		1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M 7FGM 7FGN 8KG2	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Cytosol Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Cytoplasm Positive Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Production Regulation Of Innate Immune Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Immune System Process Negative Regulation Of Signal Transduction Nucleus Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Interleukin-1 Beta Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Positive Regulation Of Defense Response Catabolic Process	Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Modification-dependent Protein Catabolic Process Proteasome Complex VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Mitotic Spindle Orientation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Microtubule Cytoskeleton Organization Involved In Mitosis Proteolysis Regulation Of Mitotic Centrosome Separation VCP-NPL4-UFD1 AAA ATPase Complex Establishment Of Spindle Localization Spindle Localization Macromolecule Catabolic Process Positive Regulation Of Cell Cycle HMG Box Domain Binding Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Proteasome Binding Ubiquitin-specific Protease Binding ERAD Pathway Autophagosome Assembly Autophagosome Organization Negative Regulation Of Hippo Signaling Nuclear Membrane Reassembly Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Genome Replication Response To Stress Microtubule-based Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Central Nervous System Development Regulation Of Response To Calcium Ion
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