FAF1 and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 33665565)
71

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FAF1	NEDD8
Description		Fas associated factor 1	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Endomembrane System CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Perinuclear Region Of Cytoplasm Ooplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Apoptotic Process Regulation Of Cell Adhesion Fas Signaling Pathway ERAD Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly
Pathways			TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29290336) Blood urea nitrogen levels ( 31152163) Body mass index and type 2 diabetes (pairwise) ( 33619380) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression and alcohol dependence ( 22064162) FEV1 ( 30804560) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Left ventricle wall thickness ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 33830993 31194737) Neutrophil percentage of white cells ( 32888494) Pancreas fat ( 34128465) Peak expiratory flow ( 30804560) Postprandial triglyceride response ( 32603185) Pulse pressure ( 30578418 27841878) QRS duration ( 21076409 30679814) Renal cell carcinoma ( 28598434) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 24509480 26818947 28869590 30718926 32499647) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)	Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		49 interacting genes: AKT1 ANXA1 ANXA7 ASCC2 CASP8 CBS CD40 CDC73 CDKN1A CREBBP CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 HSPA1B IGF2 IKBKB ITGB1BP1 NEDD8 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 PRKN RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 SPOP SUMO1 TAF1D TK1 TNNT1 TSC22D1 UBC UBE2I UROD WWP2 XIAP YTHDF3	71 interacting genes: AHR ANKRD13D ARIH2 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		11124	4738
HPRD ID		05124	04412
Ensembl ID		ENSG00000185104	ENSG00000129559
Uniprot IDs		Q9UNN5	Q15843
PDB IDs		1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M 7FGM 7FGN 8KG2	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Cytosol Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Cytoplasm Positive Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Production Regulation Of Innate Immune Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Immune System Process Negative Regulation Of Signal Transduction Nucleus Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Interleukin-1 Beta Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Positive Regulation Of Defense Response Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm
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