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EPM2A and PRKAB2
Number of citations of the paper that reports this interaction (PMID
18029386
)
31
Data Source:
BioGRID
(two hybrid)
EPM2A
PRKAB2
Gene Name
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Polysome
Plasma Membrane
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Molecular Function
Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Carbohydrate Phosphatase Activity
Starch Binding
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
Biological Process
Carbohydrate Metabolic Process
Glycogen Metabolic Process
Glycogen Biosynthetic Process
Glucose Metabolic Process
Protein Dephosphorylation
Autophagy
Nervous System Development
Pathogenesis
Peptidyl-tyrosine Dephosphorylation
Small Molecule Metabolic Process
Inositol Phosphate Dephosphorylation
Habituation
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Pathways
Glucose metabolism
Glycogen synthesis
Myoclonic epilepsy of Lafora
Glycogen storage diseases
Metabolism of carbohydrates
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Adenosine monophosphate
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
EPM2AIP1
NFU1
NHLRC1
PPP1R3D
PRKAA1
PRKAA2
PRKAB2
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
Entrez ID
7957
5565
HPRD ID
06345
04117
Ensembl ID
ENSG00000112425
ENSG00000131791
Uniprot IDs
O95278
O43741
PDB IDs
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
Enriched GO Terms of Interacting Partners
?
Regulation Of Generation Of Precursor Metabolites And Energy
Energy Reserve Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Response To Insulin
Energy Derivation By Oxidation Of Organic Compounds
Carnitine Shuttle
Generation Of Precursor Metabolites And Energy
Carnitine Transmembrane Transport
Carnitine Transport
Regulation Of Energy Homeostasis
Response To Peptide Hormone
Positive Regulation Of Glycolytic Process
Response To Peptide
Fatty Acid Biosynthetic Process
Regulation Of Lipid Biosynthetic Process
Fatty Acid Homeostasis
Cell Cycle Arrest
Insulin Receptor Signaling Pathway
Autophagy
Quaternary Ammonium Group Transport
Histone-serine Phosphorylation
Oxidation-reduction Process
Cellular Response To Glucose Starvation
Cellular Response To Insulin Stimulus
Regulation Of Glycolytic Process
Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of TOR Signaling
Regulation Of Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Positive Regulation Of Autophagy
Response To Organonitrogen Compound
Regulation Of Glycogen Metabolic Process
Long-chain Fatty Acid Transport
Histone Phosphorylation
Ammonium Transmembrane Transport
Sterol Biosynthetic Process
Regulation Of Lipid Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Anion Homeostasis
Response To Hormone
Fatty Acid Metabolic Process
Cellular Response To Peptide
Regulation Of TOR Signaling
Glycogen Metabolic Process
Fatty Acid Transport
Ammonium Transport
Negative Regulation Of Cell Cycle
Polysaccharide Metabolic Process
Cellular Response To Organonitrogen Compound
Regulation Of Fatty Acid Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
Tagcloud
?
arms
autophago
biogenesis
branched
chop
defects
disposal
encode
epilepsy
epm2b
glycogen
hyperphosphorylated
insoluble
knock
lafora
laforin
laforinmalin
lamp1
lc3
lysosomal
malin
myoclonus
overaccumulation
proteasomal
s6
slight
speculate
starvation
ubiquitinated
Tagcloud (Difference)
?
arms
autophago
biogenesis
branched
chop
defects
disposal
encode
epilepsy
epm2b
glycogen
hyperphosphorylated
insoluble
knock
lafora
laforin
laforinmalin
lamp1
lc3
lysosomal
malin
myoclonus
overaccumulation
proteasomal
s6
slight
speculate
starvation
ubiquitinated
Tagcloud (Intersection)
?