EPM2A and PRKAA1

Number of citations of the paper that reports this interaction (PMID 21728993)
6

Data Source:
BioGRID (enzymatic study)

		EPM2A	PRKAA1
Gene Name		epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	protein kinase, AMP-activated, alpha 1 catalytic subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Polysome Plasma Membrane	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane AMP-activated Protein Kinase Complex
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Carbohydrate Phosphatase Activity Starch Binding	Chromatin Binding Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Protein Dephosphorylation Autophagy Nervous System Development Pathogenesis Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process Inositol Phosphate Dephosphorylation Habituation	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Lipid Catabolic Process Protein Heterooligomerization Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Cellular Response To Hydrogen Peroxide Cellular Response To Ethanol Cellular Response To Hypoxia Response To Camptothecin Regulation Of Energy Homeostasis Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs			Adenosine monophosphate Adenosine triphosphate Phenformin
Diseases
GWAS			Gastric cancer ( 22037551)
Protein-Protein Interactions		7 interactors: EPM2AIP1 NFU1 NHLRC1 PPP1R3D PRKAA1 PRKAA2 PRKAB2	58 interactors: ABI2 ACACA AES BHLHE40 CAB39 CDX4 CFTR CRTC2 CTBP1 EEF2K EPM2A FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KRT40 L3MBTL3 MAP3K7 MDM4 MORC4 MTOR MTUS2 PFKFB2 PHC2 PLEKHA4 PNMA5 PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 VPS37B VPS52 ZBED1
Entrez ID		7957	5562
HPRD ID		06345	04115
Ensembl ID		ENSG00000112425	ENSG00000132356
Uniprot IDs		O95278	Q13131
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Regulation Of Carbohydrate Metabolic Process Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Carnitine Shuttle Generation Of Precursor Metabolites And Energy Carnitine Transmembrane Transport Carnitine Transport Regulation Of Energy Homeostasis Response To Peptide Hormone Positive Regulation Of Glycolytic Process Response To Peptide Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Cell Cycle Arrest Insulin Receptor Signaling Pathway Autophagy Quaternary Ammonium Group Transport Histone-serine Phosphorylation Oxidation-reduction Process Cellular Response To Glucose Starvation Cellular Response To Insulin Stimulus Regulation Of Glycolytic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of TOR Signaling Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Response To Organonitrogen Compound Regulation Of Glycogen Metabolic Process Long-chain Fatty Acid Transport Histone Phosphorylation Ammonium Transmembrane Transport Sterol Biosynthetic Process Regulation Of Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Anion Homeostasis Response To Hormone Fatty Acid Metabolic Process Cellular Response To Peptide Regulation Of TOR Signaling Glycogen Metabolic Process Fatty Acid Transport Ammonium Transport Negative Regulation Of Cell Cycle Polysaccharide Metabolic Process Cellular Response To Organonitrogen Compound Regulation Of Fatty Acid Metabolic Process	Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Cycle Arrest Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Gene Expression Response To Organonitrogen Compound Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Biosynthetic Process Cell Cycle Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Protein Oligomerization RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Protein Heterooligomerization Negative Regulation Of Transcription, DNA-templated Protein Phosphorylation
Tagcloud ?		arms autophago biogenesis branched chop defects disposal encode epilepsy epm2b glycogen hyperphosphorylated insoluble knock lafora laforin laforinmalin lamp1 lc3 lysosomal malin myoclonus overaccumulation proteasomal s6 slight speculate starvation ubiquitinated	abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant
Tagcloud (Difference) ?		arms autophago biogenesis branched chop defects disposal encode epilepsy epm2b glycogen hyperphosphorylated insoluble knock lafora laforin laforinmalin lamp1 lc3 malin myoclonus overaccumulation proteasomal s6 slight speculate starvation ubiquitinated	abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant
Tagcloud (Intersection) ?		lysosomal